Pocket Pet · Mus musculus · typical adult weight 0.02–0.04 kg
Diphenhydramine is dosed at 1–2 mg/kg PO, SC q12h in mice, per 130. Morrisey JK, Carpenter JW. Formulary. In: Quesenberry KE, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.796 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.6 (Emergency Drugs Used in Rodents). Diphenhydramine is used in mice for Antihistamine; anaphylaxis. Routes documented in mice: PO, SC. A typical adult mouse weighs 0.02–0.04 kg. ExoticRx lists 1 cited dose rule for Diphenhydramine in mice, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Benadryl
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| PO, SC | 1–2 mg/kg | q12h | Antihistamine; anaphylaxis | Moderate | 130. Morrisey JK, Carpenter JW. Formulary. In: Quesenberry KE, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.796 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.6 (Emergency Drugs Used in Rodents).Compilation only — we have not located an independent source that prints this figure. |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 1–2 | PO | Carpenter's Exotic Animal Formulary, 6th edTable 9.6 | 1-2 mg/kg PO, SC q12h |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
Typical range: 20–40 g
If provided, volume will be calculated alongside dose.
Reference only. Verify against current literature before clinical use.
Competitive antagonist at histamine H1 receptors. Also has anticholinergic, anti-motion sickness, and mild sedative properties.
Sedation common (first-generation). Anticholinergic effects (dry mouth, urinary retention). Ensure product does not contain xylitol or pseudoephedrine. Dogs and cats. Less effective than second-gen antihistamines for pruritus.
Species-specific contraindications and adverse-reaction reports for mice may differ from canine / feline reference data — consult the primary citations listed with each rule.
Diphenhydramine dose range in mice, with cited source references: PO, SC 1–2 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Diphenhydramine in mice: PO, SC.
Diphenhydramine is indicated in mice for: Antihistamine; anaphylaxis.
These are general warnings for Diphenhydramine across species; consult the mouse dosing table above for species-specific guidance. Sedation common (first-generation). Anticholinergic effects (dry mouth, urinary retention). Ensure product does not contain xylitol or pseudoephedrine. Dogs and cats. Less effective than second-gen antihistamines for pruritus.
Why a species-specific page? Diphenhydramine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in mice — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.