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Cryptosporidiosis in Corn Snakes

Reptile · Pantherophis guttatus · typical adult weight 0.20–0.90 kg

2 cited drugs treat Cryptosporidiosis in corn snakes: Paromomycin, Spiramycin.

Protozoal enteric infection caused by Cryptosporidium spp. — significant in calves, lambs, foals, reptiles (notably leopard geckos via C. saurophilum), and as a zoonotic concern. No reliably effective antiprotozoal in many species; supportive care remains the mainstay.

The overview above describes Cryptosporidiosis across species; the citations below are the ExoticRx dose rules scoped to corn snakes — a reference list, not new species-specific clinical guidance.

Paromomycin(Humatin)

Antibiotic
RouteDoseFrequencyIndicationEvidenceSource
PO100 mg/kgonce daily for 10 days, then twice weekly for 90Cryptosporidiosis (gastric), here with secondary esophagogastric intussusceptionAnecdotalShimizu U, Kurihara M, Tamukai K, Yamada K. Treatment of esophagogastric intussusception due to cryptosporidiosis using paromomycin in a corn snake (Pantherophis guttatus). J Vet Med Sci. 2025;87(4):389-393. doi:10.1292/jvms.24-0483 https://europepmc.org/article/MED/39924250

Spiramycin(Rovamycine)

Antibiotic
RouteDoseFrequencyIndicationEvidenceSource
PO80 mg/kgq24h x 3 treatmentsCryptosporidiosis (Cryptosporidium serpentis)ModerateGraczyk TK, Cranfield MR, Hill SL. Therapeutic efficacy of halofuginone and spiramycin treatment against Cryptosporidium serpentis (Apicomplexa: Cryptosporidiidae) infections in captive snakes. Parasitol Res. 1996;82(2):143-148. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.232 (2026-08-01, PENDING REVIEW)

Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice. Verify against current literature before clinical use.

Cryptosporidiosis in Corn Snakes: 2 Cited Drug Options | ExoticRx