Amoxicillin for Domestic Pigeons

Bird · Columba livia domestica · typical adult weight 0.30–0.50 kg

Amoxicillin is dosed at 100–200 mg/kg IM q4-8h in domestic pigeons, per 245. Dorrestein GM, Van Gogh H, Rinzema JD, et al. Comparative study of ampicillin and amoxicillin after intravenous, intramuscular and oral administration in homing pigeons (Columba livia). Res Vet Sci. 1987;42:343-348. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.405 (2026-08-01, PENDING REVIEW) doi:10.1016/s0034-5288(18)30716-1. Amoxicillin is used in domestic pigeons for Bacterial infection, Gram-positive bacterial infection, Gram-positive and gram-negative bacterial infection. Routes documented in domestic pigeons: IM, PO, SC, IM. A typical adult domestic pigeon weighs 0.30–0.50 kg. ExoticRx lists 5 cited dose rules for Amoxicillin in domestic pigeons, drawn from published veterinary references. Verify against current literature before clinical use.

US trade names: Amoxi-Tabs, Amoxil

Contraindicated in Rabbit, Guinea Pig, Chinchilla, Hamster, Degu

Rabbit: Oral beta-lactams cause fatal dysbiosis in rabbitsOral amoxicillin (and other oral beta-lactams) selectively destroy gram-positive hindgut flora in rabbits, allowing Clostridium spiroforme overgrowth and fatal enterotoxemia. Never administer oral beta-lactams to rabbits. Parenteral administration carries a lower risk than the oral route, but is not established as safe in rabbits.
Guinea Pig: Oral beta-lactams cause fatal dysbiosis in guinea pigsOral amoxicillin reliably causes Clostridium difficile-mediated fatal enterotoxemia in guinea pigs. Same mechanism as in rabbits. Parenteral administration carries a lower risk than the oral route; parenteral ceftiofur specifically has been given to guinea pigs and chinchillas without adverse effect.
Chinchilla: Oral beta-lactams cause fatal dysbiosis in chinchillasChinchillas are hindgut fermenters with the same flora dependence as rabbits and guinea pigs. Oral penicillins and oral cephalosporins trigger Clostridium overgrowth and fatal enterotoxemia. Never give oral beta-lactams; parenteral routes and trimethoprim-sulfa, fluoroquinolones, or chloramphenicol are the safer choices.
Hamster: Oral beta-lactams cause fatal enterocolitis in hamstersHamsters are exquisitely susceptible to antibiotic-associated Clostridium difficile enterocolitis — the hamster is the classic laboratory model for it. Oral penicillins and cephalosporins are reliably fatal. Never administer oral beta-lactams.
Degu: Oral beta-lactams risk fatal dysbiosis in degusDegus are caviomorph hindgut fermenters closely related to chinchillas and guinea pigs. Degu-specific data is limited, so this warning is extrapolated from those related hystricomorphs — but the shared physiology makes oral beta-lactam enterotoxemia the expected outcome. Treat as contraindicated; use the safer alternatives.

Dose ranges

Route	Dose	Frequency	Indication	Evidence	Source
IM	100–200 mg/kg	q4-8h	Bacterial infection	Moderate	245. Dorrestein GM, Van Gogh H, Rinzema JD, et al. Comparative study of ampicillin and amoxicillin after intravenous, intramuscular and oral administration in homing pigeons (Columba livia). Res Vet Sci. 1987;42:343-348. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.405 (2026-08-01, PENDING REVIEW) doi:10.1016/s0034-5288(18)30716-1
IM	50 mg/kg	q12-24h	Gram-positive bacterial infection	Moderate	236. Dorrestein GM. Studies on Pharmacokinetics of Some Antibacterial Agents in Homing Pigeons (Columba livia), Thesis: Utrecht University; 1986. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.405 (2026-08-01, PENDING REVIEW)
IM	250 mg/kg	q12-24h	Gram-positive and gram-negative bacterial infection

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Mechanism of action

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).

Side effects & warnings

CONTRAINDICATED in rabbits, guinea pigs, and hamsters (fatal dysbiosis). May cause GI upset. Cross-reactivity with other beta-lactams.

Species-specific contraindications and adverse-reaction reports for domestic pigeons may differ from canine / feline reference data — consult the primary citations listed with each rule.

Frequently asked questions

What is the dose of Amoxicillin for Domestic Pigeons?

Amoxicillin dose ranges in domestic pigeons, with cited source references: IM 100–200 mg/kg q4-8h; IM 50 mg/kg q12-24h; IM 250 mg/kg q12-24h; PO 100 mg/kg q12-24h. Reference ranges from cited sources — verify against current literature before clinical use.

How is Amoxicillin administered in Domestic Pigeons?

Documented routes for Amoxicillin in domestic pigeons: IM, PO, SC, IM.

What conditions does Amoxicillin treat in Domestic Pigeons?

Amoxicillin is indicated in domestic pigeons for: Bacterial infection, Gram-positive bacterial infection, Gram-positive and gram-negative bacterial infection.

What are the side effects of Amoxicillin in Domestic Pigeons?

These are general warnings for Amoxicillin across species; consult the domestic pigeon dosing table above for species-specific guidance. CONTRAINDICATED in rabbits, guinea pigs, and hamsters (fatal dysbiosis). May cause GI upset. Cross-reactivity with other beta-lactams.

Other Antibiotic drugs with domestic pigeon dosing

Amikacin Amoxicillin-Clavulanate Ampicillin Cefadroxil Cefotaxime Cephalexin Chlortetracycline Ciprofloxacin Clindamycin Difloxacin Doxycycline Enrofloxacin

Amoxicillin dosing in other species

African Grey Parrots Green-cheeked Conures Lovebirds Zebra Finches African Pygmy Hedgehogs Ball Pythons Bearded Dragons Blue-tongue Skinks

See all species for Amoxicillin See all drugs for Domestic Pigeons

Why a species-specific page? Amoxicillin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in domestic pigeons — the rules above are the citations specific to this species, not generic recommendations.

Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.