Bird · Columba livia domestica · typical adult weight 0.30–0.50 kg
Difloxacin is dosed at 10 mg/kg IM not stated in the cited source in domestic pigeons, per Jin et al. Pharmacokinetics of difloxacin after single intravenous, oral and intramuscular administration in pigeons. Poultry Science. 2025;104(2):104800. DOI 10.1016/j.psj.2025.104800. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC11770492/. Difloxacin is used in domestic pigeons for Single-dose pharmacokinetic study. Per the conclusion, IM or IV administration at 10 mg/kg BW is effective against bacterial infections with MIC values <= 0.1 ug/mL., bacterial infection (pharmacokinetic study dose). Routes documented in domestic pigeons: IM, IV. A typical adult domestic pigeon weighs 0.30–0.50 kg. ExoticRx lists 4 cited dose rules for Difloxacin in domestic pigeons, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Dicural
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IM | 10 mg/kg | not stated in the cited source | Single-dose pharmacokinetic study. Per the conclusion, IM or IV administration at 10 mg/kg BW is effective against bacterial infections with MIC values <= 0.1 ug/mL. |
| Weak |
| Jin et al. Pharmacokinetics of difloxacin after single intravenous, oral and intramuscular administration in pigeons. Poultry Science. 2025;104(2):104800. DOI 10.1016/j.psj.2025.104800. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC11770492/ |
| IM | 10 mg/kg | single dose | bacterial infection (pharmacokinetic study dose) | Weak | Jin YG, Liu Y, Zhang YN, Chen YX, Sun LJ, Li SH, Wang WR, Yang F. Pharmacokinetics of difloxacin after single intravenous, oral and intramuscular administration in pigeons. Poultry Science. 2025;104(2):104800. doi:10.1016/j.psj.2025.104800. PMID 39799859; PMCID PMC11770492. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC11770492/ |
| IV | 10 mg/kg | not stated in the cited source | Single-dose pharmacokinetic study. Per the conclusion, IM or IV administration at 10 mg/kg BW is effective against bacterial infections with MIC values <= 0.1 ug/mL. | Weak | Jin et al. Pharmacokinetics of difloxacin after single intravenous, oral and intramuscular administration in pigeons. Poultry Science. 2025;104(2):104800. DOI 10.1016/j.psj.2025.104800. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC11770492/ |
| IV | 10 mg/kg | single dose | bacterial infection (pharmacokinetic study dose) | Weak | Jin YG, Liu Y, Zhang YN, Chen YX, Sun LJ, Li SH, Wang WR, Yang F. Pharmacokinetics of difloxacin after single intravenous, oral and intramuscular administration in pigeons. Poultry Science. 2025;104(2):104800. doi:10.1016/j.psj.2025.104800. PMID 39799859; PMCID PMC11770492. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC11770492/ |
Need the exact dose for your patient?
These ranges are per kg. Enter your domestic pigeon's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits bacterial DNA gyrase and topoisomerase IV. Concentration-dependent bactericidal activity.
Avoid in growing animals (cartilage damage). May lower seizure threshold. Primarily approved for dogs.
Species-specific contraindications and adverse-reaction reports for domestic pigeons may differ from canine / feline reference data — consult the primary citations listed with each rule.
Difloxacin dose ranges in domestic pigeons, with cited source references: IM 10 mg/kg not stated in the cited source; IM 10 mg/kg single dose; IV 10 mg/kg not stated in the cited source; IV 10 mg/kg single dose. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Difloxacin in domestic pigeons: IM, IV.
Difloxacin is indicated in domestic pigeons for: Single-dose pharmacokinetic study. Per the conclusion, IM or IV administration at 10 mg/kg BW is effective against bacterial infections with MIC values <= 0.1 ug/mL., bacterial infection (pharmacokinetic study dose).
These are general warnings for Difloxacin across species; consult the domestic pigeon dosing table above for species-specific guidance. Avoid in growing animals (cartilage damage). May lower seizure threshold. Primarily approved for dogs.
Why a species-specific page? Difloxacin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in domestic pigeons — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.