Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Difloxacin is dosed at 5–10 mg/kg PO q24h in dogs, per Arrioja-Dechert A, editor: Compendium of Veterinary Products, ed 5, Port Huron, 1999, North American Compendiums, Inc.; Pirro F, et al: Bactericidal and inhibitory activity of enrofloxacin and other fluoroquinolones in small animal pathogens. Compend Contin Educ Pract Vet 21(Suppl):19, 1999. — Verified against Muller & Kirk's Small Animal Dermatology, 7th Ed, p.202 (2026-08-01).. Difloxacin is used in dogs for Skin infections, UTI. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Difloxacin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Dicural
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 5–10 mg/kg | q24h | 7-14 days | Skin infections, UTI | Strong | Arrioja-Dechert A, editor: Compendium of Veterinary Products, ed 5, Port Huron, 1999, North American Compendiums, Inc.; Pirro F, et al: Bactericidal and inhibitory activity of enrofloxacin and other fluoroquinolones in small animal pathogens. Compend Contin Educ Pract Vet 21(Suppl):19, 1999. — Verified against Muller & Kirk's Small Animal Dermatology, 7th Ed, p.202 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits bacterial DNA gyrase and topoisomerase IV. Concentration-dependent bactericidal activity.
Avoid in growing animals (cartilage damage). May lower seizure threshold. Primarily approved for dogs.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Difloxacin dose range in dogs, with cited source references: PO 5–10 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Difloxacin in dogs: PO.
Cited course lengths for Difloxacin in dogs include: 7-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Difloxacin is indicated in dogs for: Skin infections, UTI.
These are general warnings for Difloxacin across species; consult the dog dosing table above for species-specific guidance. Avoid in growing animals (cartilage damage). May lower seizure threshold. Primarily approved for dogs.
Why a species-specific page? Difloxacin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.