Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Difloxacin is dosed at 5–10 mg/kg PO q24h in dogs, per Arrioja-Dechert A, editor: Compendium of Veterinary Products, ed 5, Port Huron, 1999, North American Compendiums, Inc.; Pirro F, et al: Bactericidal and inhibitory activity of enrofloxacin and other fluoroquinolones in small animal pathogens. Compend Contin Educ Pract Vet 21(Suppl):19, 1999. — Verified against Muller & Kirk's Small Animal Dermatology, 7th Ed, p.202 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.202' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.190; verified by finding the drug named there. If you are holding the book, turn to p.190. — SOURCE EDITION: Muller & Kirk's Small Animal Dermatology — ISBN 9781416000280, https://openlibrary.org/isbn/9781416000280. Difloxacin is used in dogs for Skin infections, UTI. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Difloxacin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Dicural
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 5–10 mg/kg | q24h | 7-14 days | Skin infections, UTI |
| Arrioja-Dechert A, editor: Compendium of Veterinary Products, ed 5, Port Huron, 1999, North American Compendiums, Inc.; Pirro F, et al: Bactericidal and inhibitory activity of enrofloxacin and other fluoroquinolones in small animal pathogens. Compend Contin Educ Pract Vet 21(Suppl):19, 1999. — Verified against Muller & Kirk's Small Animal Dermatology, 7th Ed, p.202 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.202' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.190; verified by finding the drug named there. If you are holding the book, turn to p.190. — SOURCE EDITION: Muller & Kirk's Small Animal Dermatology — ISBN 9781416000280, https://openlibrary.org/isbn/9781416000280 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 5–10 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.267 | • 5-10 mg/kg q24h PO. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Inhibits bacterial DNA gyrase and topoisomerase IV. Concentration-dependent bactericidal activity.
Avoid in growing animals (cartilage damage). May lower seizure threshold. Primarily approved for dogs.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Difloxacin dose range in dogs, with cited source references: PO 5–10 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Difloxacin in dogs: PO.
Cited course lengths for Difloxacin in dogs include: 7-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Difloxacin is indicated in dogs for: Skin infections, UTI.
These are general warnings for Difloxacin across species; consult the dog dosing table above for species-specific guidance. Avoid in growing animals (cartilage damage). May lower seizure threshold. Primarily approved for dogs.
Why a species-specific page? Difloxacin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.