Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Amoxicillin is dosed at 20–25 mg/kg PO q12h in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.67, Amoxicillin monograph spanning p.67-69; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.69, Amoxicillin monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 | ORIGINAL SOURCE THE BOOK CITES (2026-08-20): the dose row carries superscript 9 — "20 mg/kg PO every 8 hours9 Use ammonium chloride with caution in pa" — which resolves in the monograph's own reference list to: Benson KK, Quimby JM, Dowers KL, et al. Pilot study of side effects and serum and urine concentrations of amoxicillin-clavulanic acid in azotemic and non-azotemic cats. Journal of Feline Medicine & Surgery. 2019;22(8):729-735. This records what the handbook attributes the figure to. It is NOT a statement that the reference was read or that it validates the dose.. Amoxicillin is used in dogs for Helicobacter gastritis (triple therapy component), Bacterial infections (skin, UTI, dental), Leptospirosis (initial phase, if ampicillin unavailable), Bacterial cystitis (uncomplicated). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 6 cited dose rules for Amoxicillin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Amoxi-Tabs, Amoxil
Contraindicated in Rabbit, Guinea Pig, Chinchilla, Hamster, Degu
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 20–25 mg/kg | q12h | 14-21 days (with omeprazole + metronidazole) | Helicobacter gastritis (triple therapy component) | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.67, Amoxicillin monograph spanning p.67-69; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.69, Amoxicillin monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 | ORIGINAL SOURCE THE BOOK CITES (2026-08-20): the dose row carries superscript 9 — "20 mg/kg PO every 8 hours9 Use ammonium chloride with caution in pa" — which resolves in the monograph's own reference list to: Benson KK, Quimby JM, Dowers KL, et al. Pilot study of side effects and serum and urine concentrations of amoxicillin-clavulanic acid in azotemic and non-azotemic cats. Journal of Feline Medicine & Surgery. 2019;22(8):729-735. This records what the handbook attributes the figure to. It is NOT a statement that the reference was read or that it validates the dose. |
| PO | 11–22 mg/kg | q8h | 7-14 days | Bacterial infections (skin, UTI, dental) |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 7 | IM | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.41 | 7 mg/kg i.m. q24h; 15 mg/kg i.m. q48h for depot preparations. |
| 15 | IM | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.41 | 7 mg/kg i.m. q24h; 15 mg/kg i.m. q48h for depot preparations. |
| 10 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.41 | ■ 10 mg/kg p.o. q8-12h. ■ 11-15 mg/kg p.o. q8h for bacterial cystitis. Evidence of a |
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Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
CONTRAINDICATED in rabbits, guinea pigs, and hamsters (fatal dysbiosis). May cause GI upset. Cross-reactivity with other beta-lactams.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Amoxicillin dose ranges in dogs, with cited source references: PO 20–25 mg/kg q12h; PO 11–22 mg/kg q8h; PO 22 mg/kg q8h; PO 11–22 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Amoxicillin in dogs: PO.
Cited course lengths for Amoxicillin in dogs include: 14-21 days (with omeprazole + metronidazole); 7-14 days; 14 days then doxycycline; 3-5 days (uncomplicated) or 10-14 days (complicated). Duration depends on the indication — match it to the specific dose rule in the table above.
Amoxicillin is indicated in dogs for: Helicobacter gastritis (triple therapy component), Bacterial infections (skin, UTI, dental), Leptospirosis (initial phase, if ampicillin unavailable), Bacterial cystitis (uncomplicated), Borreliosis (Lyme disease), Bordetella bronchiseptica (kennel cough).
These are general warnings for Amoxicillin across species; consult the dog dosing table above for species-specific guidance. CONTRAINDICATED in rabbits, guinea pigs, and hamsters (fatal dysbiosis). May cause GI upset. Cross-reactivity with other beta-lactams.
Why a species-specific page? Amoxicillin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| Weak |
| Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted), Amoxicillin, printed p.69 (corpus plumb p.96) — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| PO | 22 mg/kg | q8h | 14 days then doxycycline | Leptospirosis (initial phase, if ampicillin unavailable) | Strong | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.67, Amoxicillin monograph spanning p.67-69; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 — Plumb's Veterinary Drug Handbook, 10th ed (held), Amoxicillin monograph, printed p.69 (corpus PDF p.96), DOGS: "Systemic infections (extra-label): 11 - 22 mg/kg PO every 8 hours." Corroborated: Papich MG, Saunders Handbook of Veterinary Drugs, 4th ed, printed p.39: "Dogs and Cats • 6.6-20 mg/kg q8-12h PO"; BSAVA Small Animal Formulary, 10th ed, Part A: "Oral: 10 mg/kg p.o. q8-12h." [CEILING REDUCED 2026-08-12, two readers — the only 30 mg/kg amoxicillin figures in the cited book sit under the FERRETS heading.] |
| PO | 11–22 mg/kg | q12h | 3-5 days (uncomplicated) or 10-14 days (complicated) | Bacterial cystitis (uncomplicated) | Strong | ISCAID UTI Guidelines; Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.69, Amoxicillin monograph spanning p.67-69; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| PO | 20 mg/kg | q8h (30 days for borreliosis) | 30 days | Borreliosis (Lyme disease) | Weak | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted), Amoxicillin, printed p.69 (corpus plumb p.96) — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 — Plumb's Veterinary Drug Handbook, 10th ed (held), Amoxicillin monograph, printed p.69 (corpus PDF p.96), DOGS: "Borreliosis (Lyme disease) (extra-label): 20 mg/kg PO 3 times daily for 30 days." [INDICATION, DURATION AND NOTES CORRECTED 2026-08-12, two readers — the cited page prints no dental or periodontal indication for plain amoxicillin.] |
| PO | 11–22 mg/kg | q8h | 10-14 days | Bordetella bronchiseptica (kennel cough) | Weak | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted), p.96, DOGS — 'Systemic infections (extra-label): 11 - 22 mg/kg PO every 8 hours' — Plumb's 10th ed (held) printed p.69, Amoxicillin monograph spanning p.67-69; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| 11–15 |
| PO |
| BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.41 |
| ■ 10 mg/kg p.o. q8-12h. ■ 11-15 mg/kg p.o. q8h for bacterial cystitis. Evidence of a need for clavulanic acid is lacki |
| 16–33 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.41 | ion, causal organism and severity of the disease. (Doses of 16-33 mg/kg i.v. q8h are used in humans to treat serious infections.) |
| 6.6–20 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.67 | • 6.6-20 mg/kg q8-12h PO. |
| 12.5–25 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.68 | • 12.5-25 mg/kg q12h PO. (Dose is based on combined ingredients: amoxicillin |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.