Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Amoxicillin is dosed at 22–30 mg/kg PO q8h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Amoxicillin is used in dogs for Leptospirosis (initial phase, if ampicillin unavailable), Helicobacter gastritis (triple therapy component), Bacterial cystitis (uncomplicated), Bordetella bronchiseptica (kennel cough). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 6 cited dose rules for Amoxicillin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Amoxi-Tabs, Amoxil
Contraindicated in Rabbit, Guinea Pig, Chinchilla, Hamster, Degu
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 22–30 mg/kg | q8h | 14 days then doxycycline | Leptospirosis (initial phase, if ampicillin unavailable) | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| PO | 20–25 mg/kg | q12h | 14-21 days (with omeprazole + metronidazole) | Helicobacter gastritis (triple therapy component) | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| PO | 11–22 mg/kg | q12h | 3-5 days (uncomplicated) or 10-14 days (complicated) | Bacterial cystitis (uncomplicated) | Strong |
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Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
CONTRAINDICATED in rabbits, guinea pigs, and hamsters (fatal dysbiosis). May cause GI upset. Cross-reactivity with other beta-lactams.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Amoxicillin dose ranges in dogs, with cited source references: PO 22–30 mg/kg q8h; PO 20–25 mg/kg q12h; PO 11–22 mg/kg q12h; PO 11–22 mg/kg q8h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Amoxicillin in dogs: PO.
Cited course lengths for Amoxicillin in dogs include: 14 days then doxycycline; 14-21 days (with omeprazole + metronidazole); 3-5 days (uncomplicated) or 10-14 days (complicated); 10-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Amoxicillin is indicated in dogs for: Leptospirosis (initial phase, if ampicillin unavailable), Helicobacter gastritis (triple therapy component), Bacterial cystitis (uncomplicated), Bordetella bronchiseptica (kennel cough), Dental infections, periodontal disease, Bacterial infections (skin, UTI, dental).
These are general warnings for Amoxicillin across species; consult the dog dosing table above for species-specific guidance. CONTRAINDICATED in rabbits, guinea pigs, and hamsters (fatal dysbiosis). May cause GI upset. Cross-reactivity with other beta-lactams.
Why a species-specific page? Amoxicillin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| PO | 11–22 mg/kg | q8h | 10-14 days | Bordetella bronchiseptica (kennel cough) | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed, p.96, DOGS — 'Systemic infections (extra-label): 11 - 22 mg/kg PO every 8 hours' |
| PO | 20 mg/kg | q8h (30 days for borreliosis) | 7-10 days peri-dental procedure | Dental infections, periodontal disease | Strong | Plumb's Veterinary Drug Handbook, 9th Ed, Amoxicillin, printed p.69 (corpus plumb p.96) |
| PO | 11–22 mg/kg | q8h | 7-14 days | Bacterial infections (skin, UTI, dental) | Strong | Plumb's Veterinary Drug Handbook, 9th Ed, Amoxicillin, printed p.69 (corpus plumb p.96) |