ExoticRx · exoticrx.com/drugs/difloxacin
US brand names:Dicural
Difloxacin is dosed at 10 mg/kg IM single dose in domestic pigeons, per Jin YG, Liu Y, Zhang YN, Chen YX, Sun LJ, Li SH, Wang WR, Yang F. Pharmacokinetics of difloxacin after single intravenous, oral and intramuscular administration in pigeons. Poultry Science. 2025;104(2):104800. doi:10.1016/j.psj.2025.104800. PMID 39799859; PMCID PMC11770492. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC11770492/. Verify against current literature before clinical use.
Inhibits bacterial DNA gyrase and topoisomerase IV. Concentration-dependent bactericidal activity.
Avoid in growing animals (cartilage damage). May lower seizure threshold. Primarily approved for dogs.
Species references:All Dog (Domestic) drugsAll Domestic Pigeon drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 5–10 mg/kg | q24h | Strong | Arrioja-Dechert A, editor: Compendium of Veterinary Products, ed 5, Port Huron, 1999, North American Compendiums, Inc.; Pirro F, et al: Bactericidal and inhibitory activity of enrofloxacin and other fluoroquinolones in small animal pathogens. Compend Contin Educ Pract Vet 21(Suppl):19, 1999. — Verified against Muller & Kirk's Small Animal Dermatology, 7th Ed, p.202 (2026-08-01). |
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