Pocket Pet · Mus musculus · typical adult weight 0.02–0.04 kg
Buprenorphine is dosed at 0.05–0.1 mg/kg IP every 4-8 hours in mice, per Oh SS, Narver HL. Mouse and Rat Anesthesia and Analgesia. Curr Protoc. 2024 Feb;4(2):e995. doi:10.1002/cpz1.995. PMID: 38406895; PMCID: PMC10914332. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC10914332/. Buprenorphine is used in mice for Analgesia, Analgesia (postoperative/surgical pain); the study's tested and recommended dose. Per the paper it 'provides sufficient plasma concentrations for analgesia in mice for 6 to 12 h after administration, . Routes documented in mice: IP, SC. A typical adult mouse weighs 0.02–0.04 kg. ExoticRx lists 2 cited dose rules for Buprenorphine in mice, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Simbadol, Buprenex
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IP | 0.05–0.1 mg/kg | every 4-8 hours | Analgesia | Weak | Oh SS, Narver HL. Mouse and Rat Anesthesia and Analgesia. Curr Protoc. 2024 Feb;4(2):e995. doi:10.1002/cpz1.995. PMID: 38406895; PMCID: PMC10914332. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC10914332/ |
| SC | 0.9 mg/kg | single dose | Analgesia (postoperative/surgical pain); the study's tested and recommended dose. Per the paper it 'provides sufficient plasma concentrations for analgesia in mice for 6 to 12 h after administration, | Weak | Pharmacokinetics and Efficacy of a Long-lasting, Highly Concentrated Buprenorphine Solution in Mice. Journal of the American Association for Laboratory Animal Science (JAALAS), 2021. PMID 32993847; DOI 10.30802/AALAS-JAALAS-20-000049; PMC7831350. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC7831350/ |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.05–0.1 | IM | BSAVA Small Animal Formulary, 10th ed — Part B (Exotic Pets)p.58 | 0.05-0.1 mg/kg i.m., s.c. q6-12h |
| 0.1–0.2 | SC | Carpenter's Exotic Animal Formulary, 6th edTable 9.4 | 0.05-0.1 mg/kg SC q12h or 0.1-0.2 mg/kg SC |
| 0.1 | SC | Carpenter's Exotic Animal Formulary, 6th edTable 9.4 | 0.1 mg/kg SC q12h |
| 0.3–0.48 | SC | Carpenter's Exotic Animal Formulary, 6th edTable 9.4 | - 0.3-0.48 mg/kg SC 0.3-1.2 mg/kg SC q48- 72h |
| 0.05–0.1 |
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These ranges are per kg. Enter your mouse's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Partial agonist at mu-opioid receptors with high receptor affinity. Provides analgesia with a ceiling effect on respiratory depression.
OTM (oral transmucosal) absorption effective in cats. Ceiling effect limits maximum analgesia. Difficult to reverse with naloxone due to high receptor affinity.
Species-specific contraindications and adverse-reaction reports for mice may differ from canine / feline reference data — consult the primary citations listed with each rule.
Buprenorphine dose ranges in mice, with cited source references: IP 0.05–0.1 mg/kg every 4-8 hours; SC 0.9 mg/kg single dose. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Buprenorphine in mice: IP, SC.
Buprenorphine is indicated in mice for: Analgesia, Analgesia (postoperative/surgical pain); the study's tested and recommended dose. Per the paper it 'provides sufficient plasma concentrations for analgesia in mice for 6 to 12 h after administration, .
These are general warnings for Buprenorphine across species; consult the mouse dosing table above for species-specific guidance. OTM (oral transmucosal) absorption effective in cats. Ceiling effect limits maximum analgesia. Difficult to reverse with naloxone due to high receptor affinity.
Why a species-specific page? Buprenorphine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in mice — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| SC |
| Carpenter's Exotic Animal Formulary, 6th edTable 9.4 |
| 0.05-0.1 mg/kg SC q12h or 0.1-0.2 mg/kg SC |
| 1.5 | SC | Carpenter's Exotic Animal Formulary, 6th edTable 9.4 | 1.5 mg/kg SC q48h |
| 2.2 | SC | Carpenter's Exotic Animal Formulary, 6th edTable 9.4 | 2.2 mg/kg SC q24-48h |
| 0.3–1.2 | SC | Carpenter's Exotic Animal Formulary, 6th edTable 9.4 | - 0.3-0.48 mg/kg SC 0.3-1.2 mg/kg SC q48- 72h |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.