Buprenorphine for Mouses
Pocket Pet · Mus musculus · typical adult weight 0.02–0.04 kg
Buprenorphine is dosed at 0.05–0.1 mg/kg IP every 4-8 hours in mouses, per Oh SS, Narver HL. Mouse and Rat Anesthesia and Analgesia. Curr Protoc. 2024 Feb;4(2):e995. doi:10.1002/cpz1.995. PMID: 38406895; PMCID: PMC10914332. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC10914332/. Buprenorphine is used in mouses for Analgesia, Analgesia (postoperative/surgical pain); the study's tested and recommended dose. Per the paper it 'provides sufficient plasma concentrations for analgesia in mice for 6 to 12 h after administration, , Analgesia (comparator dose in murine studies; the standard formulation Bup-HCl against which Bup-LHC is compared). Route/frequency not stated in this sentence; elsewhere the paper notes Bup-HCl 'is ty. Routes documented in mouses: IP, SC, unspecified. A typical adult mouse weighs 0.02–0.04 kg. ExoticRx lists 3 cited dose rules for Buprenorphine in mouses, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Simbadol, Buprenex
Dose ranges
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IP | 0.05–0.1 mg/kg | every 4-8 hours | Analgesia | Weak | Oh SS, Narver HL. Mouse and Rat Anesthesia and Analgesia. Curr Protoc. 2024 Feb;4(2):e995. doi:10.1002/cpz1.995. PMID: 38406895; PMCID: PMC10914332. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC10914332/ |
| SC | 0.9 mg/kg | single dose | Analgesia (postoperative/surgical pain); the study's tested and recommended dose. Per the paper it 'provides sufficient plasma concentrations for analgesia in mice for 6 to 12 h after administration, | Weak | Pharmacokinetics and Efficacy of a Long-lasting, Highly Concentrated Buprenorphine Solution in Mice. Journal of the American Association for Laboratory Animal Science (JAALAS), 2021. PMID 32993847; DOI 10.30802/AALAS-JAALAS-20-000049; PMC7831350. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC7831350/ |
| unspecified | 0.1 mg/kg | See source | Analgesia (comparator dose in murine studies; the standard formulation Bup-HCl against which Bup-LHC is compared). Route/frequency not stated in this sentence; elsewhere the paper notes Bup-HCl 'is ty | Weak | Pharmacokinetics and Efficacy of a Long-lasting, Highly Concentrated Buprenorphine Solution in Mice. Journal of the American Association for Laboratory Animal Science (JAALAS), 2021. PMID 32993847; DOI 10.30802/AALAS-JAALAS-20-000049; PMC7831350. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC7831350/ |
Need the exact dose for your patient?
These ranges are per kg. Enter your mouse's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Partial agonist at mu-opioid receptors with high receptor affinity. Provides analgesia with a ceiling effect on respiratory depression.
Side effects & warnings
OTM (oral transmucosal) absorption effective in cats. Ceiling effect limits maximum analgesia. Difficult to reverse with naloxone due to high receptor affinity.
Species-specific contraindications and adverse-reaction reports for mouses may differ from canine / feline reference data — consult the primary citations listed with each rule.
Frequently asked questions
What is the dose of Buprenorphine for Mouses?
Buprenorphine dose ranges in mouses, with cited source references: IP 0.05–0.1 mg/kg every 4-8 hours; SC 0.9 mg/kg single dose; unspecified 0.1 mg/kg See source.
How is Buprenorphine administered in Mouses?
Documented routes for Buprenorphine in mouses: IP, SC, unspecified.
What conditions does Buprenorphine treat in Mouses?
Buprenorphine is indicated in mouses for: Analgesia, Analgesia (postoperative/surgical pain); the study's tested and recommended dose. Per the paper it 'provides sufficient plasma concentrations for analgesia in mice for 6 to 12 h after administration, , Analgesia (comparator dose in murine studies; the standard formulation Bup-HCl against which Bup-LHC is compared). Route/frequency not stated in this sentence; elsewhere the paper notes Bup-HCl 'is ty.
What are the side effects of Buprenorphine in Mouses?
These are general warnings for Buprenorphine across species; consult the mouse dosing table above for species-specific guidance. OTM (oral transmucosal) absorption effective in cats. Ceiling effect limits maximum analgesia. Difficult to reverse with naloxone due to high receptor affinity.
Other Analgesic drugs with mouse dosing
Buprenorphine dosing in other species
Why a species-specific page? Buprenorphine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in mouses — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.