ExoticRx · exoticrx.com/drugs/buprenorphine
Simbadol, Buprenex
Partial agonist at mu-opioid receptors with high receptor affinity. Provides analgesia with a ceiling effect on respiratory depression.
OTM (oral transmucosal) absorption effective in cats. Ceiling effect limits maximum analgesia. Difficult to reverse with naloxone due to high receptor affinity.
Species references:All African Grey Parrot drugsAll African Pygmy Hedgehog drugsAll Ball Python drugsAll Bearded Dragon drugsAll Cat (Domestic) drugsAll Chinchilla drugsAll Dog (Domestic) drugsAll Ferret drugsAll Guinea Pig drugsAll Pet Rat drugsAll Rabbit (Domestic) drugs
Controlled substance
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Buprenorphine CRI dose rule from the ExoticRx formulary. Verify against current literature before clinical use; CRI rates differ from bolus dosing and route, dilution, and monitoring matter. Sign in for the complete per-species CRI protocol set.
| Species | Route | Rate | Indication | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.003–0.005 mg/kgper hour (CRI) | Intraoperative CRI analgesia | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
Intraoperative CRI analgesia
A dog/cat sample is shown here. Cited dosing for all 11 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.