ExoticRx · exoticrx.com/drugs/buprenorphine
US brand names:Simbadol, Buprenex
Buprenorphine is dosed at 0.02–0.1 mg/kg IM q24-48h in ball pythons, per Verified against BSAVA Small Animal Formulary, 10th Ed, Part B: Exotic Pets, p.58 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.58' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.44; verified by finding the drug named there. If you are holding the book, turn to p.44. — SOURCE EDITION: BSAVA Small Animal Formulary, Part B — Exotic Pets — ISBN 9781910443712, https://openlibrary.org/isbn/9781910443712. Verify against current literature before clinical use.
Partial agonist at mu-opioid receptors with high receptor affinity. Provides analgesia with a ceiling effect on respiratory depression.
OTM (oral transmucosal) absorption effective in cats. Ceiling effect limits maximum analgesia. Difficult to reverse with naloxone due to high receptor affinity.
Controlled substance in the US
Controlled-drug status and schedules differ by country — check your local scheduling rules.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Buprenorphine CRI dose rule from the ExoticRx formulary. Verify against current literature before clinical use; CRI rates differ from bolus dosing and route, dilution, and monitoring matter. Sign in for the complete per-species CRI protocol set.
| Species | Route | Rate | Indication | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.002–0.004 mg/kg/hper hour (CRI); IV load 0.005-0.01 mg/kg first | Intraoperative CRI analgesia | Weak | Plumb's Veterinary Drug Handbook, 10th Ed (2023), PDF p.179 (printed p.152), DOGS - Analgesia b) Constant rate infusion (CRI) — Plumb's 10th ed (held) printed p.150, Buprenorphine monograph spanning p.150-154; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Intraoperative CRI analgesia
A dog/cat sample is shown here. Cited dosing for all 22 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.002–0.004 mg/kg/h | per hour (CRI); IV load 0.005-0.01 mg/kg first | Weak | Plumb's Veterinary Drug Handbook, 10th Ed (2023), PDF p.179 (printed p.152), DOGS - Analgesia b) Constant rate infusion (CRI) — Plumb's 10th ed (held) printed p.150, Buprenorphine monograph spanning p.150-154; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Dog (Domestic) | IM | 0.01–0.02 mg/kg | q6-8h | Strong | VETERGESIC Multidose 0.3 Mg/ML Solution for Injection for Dogs, Cats, and Horses [UK Datasheet]. Amersham HP7 9FB, UK: Ceva Animal Health Ltd; 2018.; VETERGESIC 0.3 Mg/ML Solution for Injection for Dogs and Cats [UK Datasheet]. Ceva Animal Health Ltd; 2018. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.179 (2026-08-01). — Plumb's 10th ed (held) printed p.152, Buprenorphine monograph spanning p.150-154; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, |
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