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Aspirin

Bufferin, Ascriptin

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Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Analgesic

Routes

PO

Indications

Anti-platelet (arterial thromboembolism prevention)Anti-platelet (low-dose)pain/inflammation

Mechanism of Action

Irreversibly acetylates cyclooxygenase (COX-1 and COX-2), inhibiting prostaglandin and thromboxane synthesis.

Side effects & warnings

TOXIC to cats (prolonged half-life, deficient glucuronidation). Use buffered only. GI ulceration. Avoid with other NSAIDs or corticosteroids. Platelet inhibition irreversible.

Species with Aspirin dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs

Evidence levels across 2 dose rules

Strong×1Moderate×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO0.5–1 mg/kgq24h (antiplatelet)StrongPlumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)PO5 mg/kgq72hModeratePlumb's Veterinary Drug Handbook, 9th Ed

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Calculate Dosage for Aspirin