Question 1

What is Colchicine used for?

Accepted Answer

Colchicine is indicated for: amyloidosis (Shar Pei), Hepatic fibrosis.

Question 2

What routes can Colchicine be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Colchicine dosing data?

Accepted Answer

Colchicine dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Colchicine a controlled substance?

Accepted Answer

Colchicine is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Colchicine?

Accepted Answer

Narrow therapeutic index. GI toxicity (nausea, vomiting, diarrhea) common. Used for hepatic fibrosis and amyloidosis in Shar Peis. Bone marrow suppression at toxic doses.

Question 6

What are the side effects of Colchicine?

Accepted Answer

Reported side effects, adverse reactions, and contraindications for Colchicine: Narrow therapeutic index. GI toxicity (nausea, vomiting, diarrhea) common. Used for hepatic fibrosis and amyloidosis in Shar Peis. Bone marrow suppression at toxic doses.

Question 7

How does Colchicine work?

Accepted Answer

Binds tubulin disrupting microtubule formation. Inhibits neutrophil migration and reduces inflammation. Anti-fibrotic properties in hepatic fibrosis.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	0.01–0.03 mg/kg	q24h	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	PO	0.01–0.03 mg/kg	q24h	Weak	Plumb's Veterinary Drug Handbook, 9th Ed

Colchicine

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Colchicine dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published source

Sample dosing (2 of 2 cited rules)

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