Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Colchicine is dosed at 0.01–0.03 mg/kg PO q24h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.337 (2026-08-01).. Colchicine is used in dogs for Hepatic fibrosis, amyloidosis (Shar Pei). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Colchicine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Colcrys
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.01–0.03 mg/kg | q24h | Long-term | Hepatic fibrosis, amyloidosis (Shar Pei) | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.337 (2026-08-01). |
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Binds tubulin disrupting microtubule formation. Inhibits neutrophil migration and reduces inflammation. Anti-fibrotic properties in hepatic fibrosis.
Narrow therapeutic index. GI toxicity (nausea, vomiting, diarrhea) common. Used for hepatic fibrosis and amyloidosis in Shar Peis. Bone marrow suppression at toxic doses.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Colchicine dose range in dogs, with cited source references: PO 0.01–0.03 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Colchicine in dogs: PO.
Cited course lengths for Colchicine in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Colchicine is indicated in dogs for: Hepatic fibrosis, amyloidosis (Shar Pei).
These are general warnings for Colchicine across species; consult the dog dosing table above for species-specific guidance. Narrow therapeutic index. GI toxicity (nausea, vomiting, diarrhea) common. Used for hepatic fibrosis and amyloidosis in Shar Peis. Bone marrow suppression at toxic doses.
Why a species-specific page? Colchicine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.