Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Colchicine is dosed at 0.01–0.03 mg/kg PO q24h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.337 (2026-08-01). — Plumb's 10th ed (held) printed p.309, Colchicine monograph spanning p.309-310; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Colchicine is used in dogs for Hepatic fibrosis, amyloidosis (Shar Pei). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Colchicine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Colcrys
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.01–0.03 mg/kg | q24h | Long-term | Hepatic fibrosis, amyloidosis (Shar Pei) | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.337 (2026-08-01). — Plumb's 10th ed (held) printed p.309, Colchicine monograph spanning p.309-310; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.01 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.117 | Initial dose 0.01 mg/kg p.o. q24h and, if no adverse GI effects, increase in incremental amounts every 3-4 days t |
| 0.03 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.117 | in incremental amounts every 3-4 days to a maximum dose of 0.03 mg/kg p.o. q12h |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Binds tubulin disrupting microtubule formation. Inhibits neutrophil migration and reduces inflammation. Anti-fibrotic properties in hepatic fibrosis.
Narrow therapeutic index. GI toxicity (nausea, vomiting, diarrhea) common. Used for hepatic fibrosis and amyloidosis in Shar Peis. Bone marrow suppression at toxic doses.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Colchicine dose range in dogs, with cited source references: PO 0.01–0.03 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Colchicine in dogs: PO.
Cited course lengths for Colchicine in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Colchicine is indicated in dogs for: Hepatic fibrosis, amyloidosis (Shar Pei).
These are general warnings for Colchicine across species; consult the dog dosing table above for species-specific guidance. Narrow therapeutic index. GI toxicity (nausea, vomiting, diarrhea) common. Used for hepatic fibrosis and amyloidosis in Shar Peis. Bone marrow suppression at toxic doses.
Why a species-specific page? Colchicine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.