ExoticRx · exoticrx.com/drugs/buprenorphine-transmucosal-simbadol
US brand names:Simbadol
Buprenorphine Transmucosal (Simbadol) is dosed at 0.24 mg/kg SC q24h SC in cats, per SIMBADOL - Buprenorphine Injection for Cats [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3395bb4d-e032-4c16-81cf-d8f364033bb8 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.180 (2026-08-01).. Verify against current literature before clinical use.
High-concentration buprenorphine providing 24-hour analgesia from a single SC injection. Partial mu-opioid agonist with ceiling effect on respiratory depression.
Cats ONLY — not approved for dogs. Single SC injection provides 24-hour pain control. Sedation, decreased appetite, and hyperthermia possible. Do not combine with full mu agonists.
Species references:All Cat (Domestic) drugs
Controlled substance in the US
Controlled-drug status and schedules differ by country — check your local scheduling rules.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | SC | 0.24 mg/kg | q24h SC | Strong | SIMBADOL - Buprenorphine Injection for Cats [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3395bb4d-e032-4c16-81cf-d8f364033bb8 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.180 (2026-08-01). |
| Cat (Domestic) | SC | 0.24 mg/kg | Single SC injection q24h | Strong | SIMBADOL - Buprenorphine Injection for Cats [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2017. Distributed by John Wiley & Sons, Inc. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3395bb4d-e032-4c16-81cf-d8f364033bb8 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.180 (2026-08-01). |
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