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Buprenorphine Transmucosal (Simbadol)

Simbadol

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Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Miscellaneous

Routes

SC

Indications

Acute pain management (trauma/injury)Post-operative analgesia (24-hour)

Mechanism of Action

High-concentration buprenorphine providing 24-hour analgesia from a single SC injection. Partial mu-opioid agonist with ceiling effect on respiratory depression.

Side effects & warnings

Cats ONLY — not approved for dogs. Single SC injection provides 24-hour pain control. Sedation, decreased appetite, and hyperthermia possible. Do not combine with full mu agonists.

Species with Buprenorphine Transmucosal (Simbadol) dosing data (2 dose rules)

Cat (Domestic)

Species references:All Cat (Domestic) drugs

Controlled Substance

Controlled substance

Evidence levels across 2 dose rules

Strong×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 2 published sources

  • · Simbadol FDA Product Label
  • · Simbadol FDA Product Label; AAFP Pain Management Guidelines

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Cat (Domestic)SC0.24 mg/kgSingle SC injection q24hStrongSimbadol FDA Product Label; AAFP Pain Management Guidelines
Cat (Domestic)SC0.24 mg/kgq24h SCStrongSimbadol FDA Product Label

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Calculate Dosage for Buprenorphine Transmucosal (Simbadol)