ExoticRx · exoticrx.com/drugs/apomorphine
US brand names:Clevor
Apomorphine is dosed at 0.04 mg/kg SC not stated in source in ferrets, per Dunayer E. Toxicology of ferrets. Vet Clin North Am Exot Anim Pract. 2008;11:301-314. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.954 — Carpenter's Exotic Animal Formulary 6th ed, Table 11.10 (Miscellaneous Agents Used in Ferrets.a). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Verify against current literature before clinical use.
Dopamine D2 receptor agonist in the chemoreceptor trigger zone (CRTZ), directly stimulating the vomiting center. Most reliable emetic for dogs.
Dogs ONLY — cats lack appropriate CRTZ dopamine receptors (use dexmedetomidine instead). Respiratory depression at high doses. Naloxone can reverse the CNS and respiratory effects, but does NOT stop apomorphine-induced vomiting and does not reverse its cardiovascular effects (Plumb's 10th ed corpus p.119-120); it can reverse. Do NOT repeat if first dose fails.
Species references:All Dog (Domestic) drugsAll Ferret drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | Conjunctival | 0.25 mg/kg | Single application; flush eye once vomiting begins | Strong | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.92, Apomorphine monograph spanning p.92-93; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 | ORIGINAL SOURCE THE BOOK CITES (2026-08-20): the dose row carries superscript 16 — "0.25 mg/kg PO (one 6.5 mg tablet per 26 kg)16" — which resolves in the monograph's own reference list to: Apomorphine Emetic Tablets [Australian Product Label]. Jurox Pty Limited; 2012. This records what the handbook attributes the figure to. It is NOT a statement that the reference was read or that it validates the dose. |
| Dog (Domestic) | IV | 0.03–0.04 mg/kg | Single IV dose |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.
| Fischer C, Drobatz KJ, Thawley VJ. Evaluation of subcutaneous versus intravenous administration of apomorphine for induction of emesis in dogs. J Am Vet Med Assoc. 2021;259(3):283-287. / 1. Khan SA, McLean MK, Slater M, Hansen S, Zawistowski S. Effectiveness and adverse effects of the use of apomorphine and 3% hydrogen peroxide solution to induce emesis in dogs. J Am Vet Med Assoc. 2012;241(9):1179-1184. doi:10.2460/javma.259.3.283 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.121 (2026-08-01). — Plumb's 10th ed (held) printed p.92, Apomorphine monograph spanning p.92-93; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 RATE/REVERSAL WORDING CORRECTED 2026-08-12: Plumb's 10th ed, Apomorphine monograph, corpus p.119: "Can cause protracted vomiting; naloxone should reverse CNS effects or cardiorespiratory depression […]" Corpus p.120: "Naloxone may reverse CNS and respiratory effects but does not reverse apomorphine-induced cardiovascular effects." The previous note read "Naloxone reverses if needed", which a clinician facing protracted vomiting would act on. |