ExoticRx · exoticrx.com/drugs/apomorphine
US brand names:Clevor
Apomorphine is dosed at 0.04 mg/kg SC not stated in source in ferrets, per Dunayer E. Toxicology of ferrets. Vet Clin North Am Exot Anim Pract. 2008;11:301-314. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.954 — Carpenter's Exotic Animal Formulary 6th ed, Table 11.10 (Miscellaneous Agents Used in Ferrets.a). Verify against current literature before clinical use.
Dopamine D2 receptor agonist in the chemoreceptor trigger zone (CRTZ), directly stimulating the vomiting center. Most reliable emetic for dogs.
Dogs ONLY — cats lack appropriate CRTZ dopamine receptors (use dexmedetomidine instead). Respiratory depression at high doses. Naloxone can reverse the CNS and respiratory effects, but does NOT stop apomorphine-induced vomiting and does not reverse its cardiovascular effects (Plumb's 10th ed); it can reverse. Do NOT repeat if first dose fails.
Species references:All Dog (Domestic) drugsAll Ferret drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | Conjunctival | 0.25 mg/kg | Single application; flush eye once vomiting begins | Strong | Plumb's Veterinary Drug Handbook, 10th ed (2023) — Plumb's 10th ed printed p.92, Apomorphine monograph spanning p.92-93. | ORIGINAL SOURCE THE BOOK CITES (2026-08-20): the dose row carries superscript 16 — "0.25 mg/kg PO (one 6.5 mg tablet per 26 kg)16" — which resolves in the monograph's own reference list to: Apomorphine Emetic Tablets [Australian Product Label]. Jurox Pty Limited; 2012. This records what the handbook attributes the figure to. It is NOT a statement that the reference was read or that it validates the dose.Compilation only — we have not located an independent source that prints this figure. |
| Dog (Domestic) | IV | 0.03–0.04 mg/kg | Single IV dose | Strong | Fischer C, Drobatz KJ, Thawley VJ. Evaluation of subcutaneous versus intravenous administration of apomorphine for induction of emesis in dogs. J Am Vet Med Assoc. 2021;259(3):283-287. / 1. Khan SA, McLean MK, Slater M, Hansen S, Zawistowski S. Effectiveness and adverse effects of the use of apomorphine and 3% hydrogen peroxide solution to induce emesis in dogs. J Am Vet Med Assoc. 2012;241(9):1179-1184. — Plumb's 10th ed printed p.92, Apomorphine monograph spanning p.92-93. |
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