ExoticRx · exoticrx.com/drugs/apomorphine
US brand names:Apoquel Emetic
Apomorphine is dosed at 0.25 mg/kg Conjunctival Single application; flush eye once vomiting begins in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Dopamine D2 receptor agonist in the chemoreceptor trigger zone (CRTZ), directly stimulating the vomiting center. Most reliable emetic for dogs.
Dogs ONLY — cats lack appropriate CRTZ dopamine receptors (use dexmedetomidine instead). Respiratory depression at high doses. Naloxone can reverse. Do NOT repeat if first dose fails.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | Conjunctival | 0.25 mg/kg | Single application; flush eye once vomiting begins | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| Dog (Domestic) | IV | 0.03–0.04 mg/kg | Single IV dose | Strong | Fischer C, Drobatz KJ, Thawley VJ. Evaluation of subcutaneous versus intravenous administration of apomorphine for induction of emesis in dogs. J Am Vet Med Assoc. 2021;259(3):283-287. / 1. Khan SA, McLean MK, Slater M, Hansen S, Zawistowski S. Effectiveness and adverse effects of the use of apomorphine and 3% hydrogen peroxide solution to induce emesis in dogs. J Am Vet Med Assoc. 2012;241(9):1179-1184. doi:10.2460/javma.259.3.283 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.121 (2026-08-01). |
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