Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Apomorphine is dosed at 0.25 mg/kg Conjunctival Single application; flush eye once vomiting begins in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.92, Apomorphine monograph spanning p.92-93; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 | ORIGINAL SOURCE THE BOOK CITES (2026-08-20): the dose row carries superscript 16 — "0.25 mg/kg PO (one 6.5 mg tablet per 26 kg)16" — which resolves in the monograph's own reference list to: Apomorphine Emetic Tablets [Australian Product Label]. Jurox Pty Limited; 2012. This records what the handbook attributes the figure to. It is NOT a statement that the reference was read or that it validates the dose.. Apomorphine is used in dogs for Emesis induction (conjunctival route), Emesis induction (in-clinic). Routes documented in dogs: Conjunctival, IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Apomorphine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Clevor
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| Conjunctival | 0.25 mg/kg | Single application; flush eye once vomiting begins | Single use; rinse eye thoroughly with saline after emesis induced | Emesis induction (conjunctival route) | Strong | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.92, Apomorphine monograph spanning p.92-93; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 | ORIGINAL SOURCE THE BOOK CITES (2026-08-20): the dose row carries superscript 16 — "0.25 mg/kg PO (one 6.5 mg tablet per 26 kg)16" — which resolves in the monograph's own reference list to: Apomorphine Emetic Tablets [Australian Product Label]. Jurox Pty Limited; 2012. This records what the handbook attributes the figure to. It is NOT a statement that the reference was read or that it validates the dose. |
| IV | 0.03–0.04 mg/kg | Single IV dose | Single dose; onset within 2-5 minutes IV; do NOT repeat if ineffective | Emesis induction (in-clinic) | Strong | Fischer C, Drobatz KJ, Thawley VJ. Evaluation of subcutaneous versus intravenous administration of apomorphine for induction of emesis in dogs. J Am Vet Med Assoc. 2021;259(3):283-287. / 1. Khan SA, McLean MK, Slater M, Hansen S, Zawistowski S. Effectiveness and adverse effects of the use of apomorphine and 3% hydrogen peroxide solution to induce emesis in dogs. J Am Vet Med Assoc. 2012;241(9):1179-1184. doi:10.2460/javma.259.3.283 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.121 (2026-08-01). — Plumb's 10th ed (held) printed p.92, Apomorphine monograph spanning p.92-93; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 RATE/REVERSAL WORDING CORRECTED 2026-08-12: Plumb's 10th ed, Apomorphine monograph, corpus p.119: "Can cause protracted vomiting; naloxone should reverse CNS effects or cardiorespiratory depression […]" Corpus p.120: "Naloxone may reverse CNS and respiratory effects but does not reverse apomorphine-induced cardiovascular effects." The previous note read "Naloxone reverses if needed", which a clinician facing protracted vomiting would act on. |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (%) | Route | Source | As printed |
|---|---|---|---|
| 0.9 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.77 | • Dissolve 6-mg tablet in 1-2 mL of 0.9% saline solution and instill directly in con- |
| Dose (mcg/kg) | Route | Source | As printed |
|---|---|---|---|
| 40 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.46 | 0.2 mg/kg s.c. (authorized dose), 20-40 μg (micrograms)/kg i.v. (non-authorized dose and route but some evidence to suggest is at least as effe |
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Dopamine D2 receptor agonist in the chemoreceptor trigger zone (CRTZ), directly stimulating the vomiting center. Most reliable emetic for dogs.
Dogs ONLY — cats lack appropriate CRTZ dopamine receptors (use dexmedetomidine instead). Respiratory depression at high doses. Naloxone can reverse the CNS and respiratory effects, but does NOT stop apomorphine-induced vomiting and does not reverse its cardiovascular effects (Plumb's 10th ed corpus p.119-120); it can reverse. Do NOT repeat if first dose fails.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Apomorphine dose ranges in dogs, with cited source references: Conjunctival 0.25 mg/kg Single application; flush eye once vomiting begins; IV 0.03–0.04 mg/kg Single IV dose. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Apomorphine in dogs: Conjunctival, IV.
Cited course lengths for Apomorphine in dogs include: Single use; rinse eye thoroughly with saline after emesis induced; Single dose; onset within 2-5 minutes IV; do NOT repeat if ineffective. Duration depends on the indication — match it to the specific dose rule in the table above.
Apomorphine is indicated in dogs for: Emesis induction (conjunctival route), Emesis induction (in-clinic).
These are general warnings for Apomorphine across species; consult the dog dosing table above for species-specific guidance. Dogs ONLY — cats lack appropriate CRTZ dopamine receptors (use dexmedetomidine instead). Respiratory depression at high doses. Naloxone can reverse the CNS and respiratory effects, but does NOT stop apomorphine-induced vomiting and does not reverse its cardiovascular effects (Plumb's 10th ed corpus p.119-120); it can reverse. Do NOT repeat if first dose fails.
Why a species-specific page? Apomorphine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| Dose (mg/kg) | Route | Source | As printed |
|---|
| 0.2 | SC | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.46 | 0.2 mg/kg s.c. (authorized dose), 20-40 μg (micrograms)/kg i.v. (non-authorized dose and route |
| 0.03–0.05 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.77 | • 0.03-0.05 mg/kg IV or IM. |
| 0.1 | SC | Papich Saunders Handbook of Veterinary Drugs, 4th edp.77 | • 0.1 mg/kg SQ. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.