Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Mannitol 20% Injectable is dosed at 500–1000 mg/kg IV Over 15-20 min; may repeat q4-6h x 2-3 doses in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted), Mannitol, p.795 (corpus PDF p.822), DOGS/CATS - increased intracranial pressure; repeat window per BSAVA Small Animal Formulary 10th Ed Part A, p.242 — SOURCE EDITION: BSAVA Small Animal Formulary, Part A — Canine and Feline — ISBN 9781910443705, https://openlibrary.org/isbn/9781910443705; Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Mannitol 20% Injectable is used in dogs for Acute head trauma (ICP reduction). Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Mannitol 20% Injectable in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Osmitrol 20%
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 500–1000 mg/kg | Over 15-20 min; may repeat q4-6h x 2-3 doses | Bolus over 15-20 min; may repeat 2-3 times at 4-6h intervals |
| Acute head trauma (ICP reduction) |
| Weak |
| Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted), Mannitol, p.795 (corpus PDF p.822), DOGS/CATS - increased intracranial pressure; repeat window per BSAVA Small Animal Formulary 10th Ed Part A, p.242 — SOURCE EDITION: BSAVA Small Animal Formulary, Part A — Canine and Feline — ISBN 9781910443705, https://openlibrary.org/isbn/9781910443705; Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (%) | Route | Source | As printed |
|---|---|---|---|
| 25 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.499 | • Glaucoma or central nervous system (CNS) edema: 0.25-2 g/kg of 15%-25% |
| 15 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.499 | • Glaucoma or central nervous system (CNS) edema: 0.25-2 g/kg of 15%-25% |
| 25 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.499 | • Diuretic: 1 g/kg of 5%-25% solution IV to maintain urine flow. |
| 5 | IV |
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Osmotically active sugar alcohol that increases plasma osmolality, drawing fluid from brain and ocular tissues. Also promotes osmotic diuresis in renal tubules.
For acute head trauma/glaucoma emergencies. Crystallizes at low temperature — warm and use in-line filter. Contraindicated in anuric renal failure and pulmonary edema.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Mannitol 20% Injectable dose range in dogs, with cited source references: IV 500–1000 mg/kg Over 15-20 min; may repeat q4-6h x 2-3 doses. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Mannitol 20% Injectable in dogs: IV.
Cited course lengths for Mannitol 20% Injectable in dogs include: Bolus over 15-20 min; may repeat 2-3 times at 4-6h intervals. Duration depends on the indication — match it to the specific dose rule in the table above.
Mannitol 20% Injectable is indicated in dogs for: Acute head trauma (ICP reduction).
These are general warnings for Mannitol 20% Injectable across species; consult the dog dosing table above for species-specific guidance. For acute head trauma/glaucoma emergencies. Crystallizes at low temperature — warm and use in-line filter. Contraindicated in anuric renal failure and pulmonary edema.
Why a species-specific page? Mannitol 20% Injectable pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.499 |
| • Diuretic: 1 g/kg of 5%-25% solution IV to maintain urine flow. |
| Dose (g/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.25–2 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.258 | 0.25-2 g/kg i.v. infusion of 15-20% solution. There is some evidence that higher doses have greater |
| 0.25–1 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.258 | ffect, but lower doses allow for repeated boluses. Doses of 0.25-1.0 g/kg are recommended. The dose is given over 20-30 min. The dose may be repeated on |
| 0.5–2 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.258 | • Acute glaucoma (if refractory to topical treatments): 0.5-2 g/kg i.v. infusion over 30 min. Withholding water for the first few hours after adm |
| 0.25–0.5 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.258 | failure (as an alternative to using furosemide): 0.25-0.5 g/kg i.v. infusion over 5-10 min. If successful can repeat in 4 hours. Rehydrate the patient p |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
| 0.25–2 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.499 | • Glaucoma or central nervous system (CNS) edema: 0.25-2 g/kg of 15%-25% |
| 0.1 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.499 | • Fluid expansion: 0.5-2 g/kg IV (or 0.1 g/kg/hr). |
| 0.5–2 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.499 | • Fluid expansion: 0.5-2 g/kg IV (or 0.1 g/kg/hr). |
| 1 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.499 | • Diuretic: 1 g/kg of 5%-25% solution IV to maintain urine flow. |