Skip to main content

Dantrolene Injectable for Dog

Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg

Dantrolene Injectable is used in dog for Malignant hyperthermia. Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Dantrolene Injectable in dog, drawn from published veterinary references. Verify against current literature before clinical use.

Trade names: Dantrium IV, Ryanodex

Dose ranges

RouteDoseFrequencyDurationIndicationEvidenceSource
IV1–3.5 mg/kgIV push; may repeat q5-10min up to 10mg/kg totalRepeat until muscle rigidity resolves or max dose; follow with oral for 24-48hMalignant hyperthermiaModeratePlumb's Veterinary Drug Handbook, 9th Ed; Veterinary Anesthesia Textbooks

Need the exact dose for your patient?

These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.

Calculate for this dog →

Mechanism of action

Directly inhibits calcium release from the sarcoplasmic reticulum by blocking ryanodine receptors, preventing excitation-contraction coupling in skeletal muscle.

Side effects & warnings

Primary treatment for malignant hyperthermia. Mix requires warming and vigorous shaking. Hepatotoxic with chronic oral use. Muscle weakness expected effect.

Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.

Other Miscellaneous drugs with dog dosing

ApomorphineBenazepril Flavored OralCalcium Chloride InjectableCorn Syrup (Hypoglycemia Rescue)Dextrose 50%Enrofloxacin Otic SolutionEpinephrine Auto-Injector (Veterinary)Firocoxib InjectionHydrogen Peroxide 3% (Emetic)Magnesium Sulfate InjectableMannitol 20% InjectableMaropitant Subcutaneous

Dantrolene Injectable dosing in other species

Cat
See all species for Dantrolene InjectableSee all drugs for Dog

Why a species-specific page? Dantrolene Injectable pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.

Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.