Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Dantrolene Injectable is dosed at 1–3.5 mg/kg IV IV push, repeat to clinical effect in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted); Veterinary Anesthesia Textbooks — Plumb's 10th ed (held) printed p.339, Dantrolene monograph spanning p.339-340; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.340, Dantrolene monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Dantrolene Injectable is used in dogs for Malignant hyperthermia. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Dantrolene Injectable in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Dantrium IV, Ryanodex
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 1–3.5 mg/kg | IV push, repeat to clinical effect | Repeat until muscle rigidity resolves or max dose; follow with oral for 24-48h | Malignant hyperthermia | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted); Veterinary Anesthesia Textbooks — Plumb's 10th ed (held) printed p.339, Dantrolene monograph spanning p.339-340; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.340, Dantrolene monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 2–5 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.124 | 2-5 mg/kg i.v. |
| 0.5–2 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.124 | 0.5-2 mg/kg p.o. q12h. Darbepoetin (Aranesp*) POM |
| 2–3 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.234 | • Prevention of malignant hyperthermia: 2-3 mg/kg IV, (up to 5-10 mg/kg). |
| 5–10 | IV |
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Directly inhibits calcium release from the sarcoplasmic reticulum by blocking ryanodine receptors, preventing excitation-contraction coupling in skeletal muscle.
Primary treatment for malignant hyperthermia. Mix requires warming and vigorous shaking. Hepatotoxic with chronic oral use. Muscle weakness expected effect.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Dantrolene Injectable dose range in dogs, with cited source references: IV 1–3.5 mg/kg IV push, repeat to clinical effect. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Dantrolene Injectable in dogs: IV.
Cited course lengths for Dantrolene Injectable in dogs include: Repeat until muscle rigidity resolves or max dose; follow with oral for 24-48h. Duration depends on the indication — match it to the specific dose rule in the table above.
Dantrolene Injectable is indicated in dogs for: Malignant hyperthermia.
These are general warnings for Dantrolene Injectable across species; consult the dog dosing table above for species-specific guidance. Primary treatment for malignant hyperthermia. Mix requires warming and vigorous shaking. Hepatotoxic with chronic oral use. Muscle weakness expected effect.
Why a species-specific page? Dantrolene Injectable pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.234 |
| • Prevention of malignant hyperthermia: 2-3 mg/kg IV, (up to 5-10 mg/kg). |
| 2.5–3 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.235 | • Malignant hyperthermia crisis: doses of 2.5-3 mg/kg IV rapid bolus (up to |
| 5–10 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.235 | 5-10 mg/kg). |
| 1–5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.235 | • Urethral relaxation: 1-5 mg/kg q8h PO or 0.5-1.0 mg/kg IV (up to 5-10 mg/kg). |
| 5–10 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.235 | • Urethral relaxation: 1-5 mg/kg q8h PO or 0.5-1.0 mg/kg IV (up to 5-10 mg/kg). |
| 0.5–1 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.235 | • Urethral relaxation: 1-5 mg/kg q8h PO or 0.5-1.0 mg/kg IV (up to 5-10 mg/kg). |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.