Cat · Felis catus · typical adult weight 2.50–7.00 kg
Dantrolene Injectable is dosed at 1 mg/kg IV single dose in cats, per Plumb's Veterinary Drug Handbook, 10th ed (2023), Dantrolene, corpus p.367 (printed p.340), CATS: '1 mg/kg IV as a single dose was effective in male cats under experimental conditions' (refs 8,9 = Straeter-Knowlen M et al. Urethral pressure response to smooth and skeletal muscle relaxants in anesthetized, adult male cats with naturally acquired urethral obstruction. Am J Vet Res. 1995;56(7):919-923; and Straeter-Knowlen IM et al. Am J Vet Res. 1994;55(12):1739-1744). Corroborated by Papich 4th ed, corpus p.234 (printed p.206): 'To relax the urethra in cats, the most effective dose is 1 mg/kg IV.'. Dantrolene Injectable is used in cats for Malignant hyperthermia. Routes documented in cats: IV. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Dantrolene Injectable in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Dantrium IV, Ryanodex
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 1 mg/kg | single dose | Repeat until signs resolve; max 10mg/kg total | Malignant hyperthermia | Weak | Plumb's Veterinary Drug Handbook, 10th ed (2023), Dantrolene, corpus p.367 (printed p.340), CATS: '1 mg/kg IV as a single dose was effective in male cats under experimental conditions' (refs 8,9 = Straeter-Knowlen M et al. Urethral pressure response to smooth and skeletal muscle relaxants in anesthetized, adult male cats with naturally acquired urethral obstruction. Am J Vet Res. 1995;56(7):919-923; and Straeter-Knowlen IM et al. Am J Vet Res. 1994;55(12):1739-1744). Corroborated by Papich 4th ed, corpus p.234 (printed p.206): 'To relax the urethra in cats, the most effective dose is 1 mg/kg IV.' |
Need the exact dose for your patient?
These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Directly inhibits calcium release from the sarcoplasmic reticulum by blocking ryanodine receptors, preventing excitation-contraction coupling in skeletal muscle.
Primary treatment for malignant hyperthermia. Mix requires warming and vigorous shaking. Hepatotoxic with chronic oral use. Muscle weakness expected effect.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Dantrolene Injectable dose range in cats, with cited source references: IV 1 mg/kg single dose. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Dantrolene Injectable in cats: IV.
Cited course lengths for Dantrolene Injectable in cats include: Repeat until signs resolve; max 10mg/kg total. Duration depends on the indication — match it to the specific dose rule in the table above.
Dantrolene Injectable is indicated in cats for: Malignant hyperthermia.
These are general warnings for Dantrolene Injectable across species; consult the cat dosing table above for species-specific guidance. Primary treatment for malignant hyperthermia. Mix requires warming and vigorous shaking. Hepatotoxic with chronic oral use. Muscle weakness expected effect.
Why a species-specific page? Dantrolene Injectable pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.