Cat · Felis catus · typical adult weight 2.50–7.00 kg
Dantrolene Injectable is dosed at 1 mg/kg IV single dose in cats, per Plumb's Veterinary Drug Handbook, 10th ed (2023), Dantrolene, corpus p.367 (printed p.340), CATS: '1 mg/kg IV as a single dose was effective in male cats under experimental conditions' (refs 8,9 = Straeter-Knowlen M et al. Urethral pressure response to smooth and skeletal muscle relaxants in anesthetized, adult male cats with naturally acquired urethral obstruction. Am J Vet Res. 1995;56(7):919-923; and Straeter-Knowlen IM et al. Am J Vet Res. 1994;55(12):1739-1744). Corroborated by Papich 4th ed, corpus p.234 (printed p.206): 'To relax the urethra in cats, the most effective dose is 1 mg/kg IV.' — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855. Dantrolene Injectable is used in cats for Functional urethral obstruction due to increased external urethral tone (male cats, experimental, may combine with prazosin). Routes documented in cats: IV. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Dantrolene Injectable in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Dantrium IV, Ryanodex
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 1 mg/kg | single dose | Repeat until signs resolve; max 10mg/kg total | Functional urethral obstruction due to increased external urethral tone (male cats, experimental, may combine with prazosin) | Weak | Plumb's Veterinary Drug Handbook, 10th ed (2023), Dantrolene, corpus p.367 (printed p.340), CATS: '1 mg/kg IV as a single dose was effective in male cats under experimental conditions' (refs 8,9 = Straeter-Knowlen M et al. Urethral pressure response to smooth and skeletal muscle relaxants in anesthetized, adult male cats with naturally acquired urethral obstruction. Am J Vet Res. 1995;56(7):919-923; and Straeter-Knowlen IM et al. Am J Vet Res. 1994;55(12):1739-1744). Corroborated by Papich 4th ed, corpus p.234 (printed p.206): 'To relax the urethra in cats, the most effective dose is 1 mg/kg IV.' — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 2–5 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.124 | 2-5 mg/kg i.v. |
| 0.5–2 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.124 | 0.5-2 mg/kg p.o. q12h. Darbepoetin (Aranesp*) POM |
| 0.5–2 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.235 | • Muscle relaxation: 0.5-2 mg/kg q12h PO. |
| 1–2 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.235 | • Relaxation of urethra: 1-2 mg/kg q8h PO. D |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Directly inhibits calcium release from the sarcoplasmic reticulum by blocking ryanodine receptors, preventing excitation-contraction coupling in skeletal muscle.
Primary treatment for malignant hyperthermia. Mix requires warming and vigorous shaking. Hepatotoxic with chronic oral use. Muscle weakness expected effect.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Dantrolene Injectable dose range in cats, with cited source references: IV 1 mg/kg single dose. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Dantrolene Injectable in cats: IV.
Cited course lengths for Dantrolene Injectable in cats include: Repeat until signs resolve; max 10mg/kg total. Duration depends on the indication — match it to the specific dose rule in the table above.
Dantrolene Injectable is indicated in cats for: Functional urethral obstruction due to increased external urethral tone (male cats, experimental, may combine with prazosin).
These are general warnings for Dantrolene Injectable across species; consult the cat dosing table above for species-specific guidance. Primary treatment for malignant hyperthermia. Mix requires warming and vigorous shaking. Hepatotoxic with chronic oral use. Muscle weakness expected effect.
Why a species-specific page? Dantrolene Injectable pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.