Cat · Felis catus · typical adult weight 2.50–7.00 kg
Buprenorphine Transmucosal (Simbadol) is dosed at 0.24 mg/kg SC Single SC injection q24h in cats, per SIMBADOL - Buprenorphine Injection for Cats [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2017. Distributed by John Wiley & Sons, Inc. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3395bb4d-e032-4c16-81cf-d8f364033bb8 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.180 (2026-08-01).. Buprenorphine Transmucosal (Simbadol) is used in cats for Post-operative analgesia (24-hour), Acute pain management (trauma/injury). Routes documented in cats: SC. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 2 cited dose rules for Buprenorphine Transmucosal (Simbadol) in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Simbadol
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| SC | 0.24 mg/kg | Single SC injection q24h | Single injection provides 24-hour analgesia; repeat once daily if needed up to 3 days | Post-operative analgesia (24-hour) | Strong | SIMBADOL - Buprenorphine Injection for Cats [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2017. Distributed by John Wiley & Sons, Inc. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3395bb4d-e032-4c16-81cf-d8f364033bb8 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.180 (2026-08-01). |
| SC | 0.24 mg/kg | q24h SC | Up to 3 days; reassess pain and transition to multimodal protocol | Acute pain management (trauma/injury) | Strong | SIMBADOL - Buprenorphine Injection for Cats [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3395bb4d-e032-4c16-81cf-d8f364033bb8 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.180 (2026-08-01). |
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These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
High-concentration buprenorphine providing 24-hour analgesia from a single SC injection. Partial mu-opioid agonist with ceiling effect on respiratory depression.
Cats ONLY — not approved for dogs. Single SC injection provides 24-hour pain control. Sedation, decreased appetite, and hyperthermia possible. Do not combine with full mu agonists.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Buprenorphine Transmucosal (Simbadol) dose ranges in cats, with cited source references: SC 0.24 mg/kg Single SC injection q24h; SC 0.24 mg/kg q24h SC. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Buprenorphine Transmucosal (Simbadol) in cats: SC.
Cited course lengths for Buprenorphine Transmucosal (Simbadol) in cats include: Single injection provides 24-hour analgesia; repeat once daily if needed up to 3 days; Up to 3 days; reassess pain and transition to multimodal protocol. Duration depends on the indication — match it to the specific dose rule in the table above.
Buprenorphine Transmucosal (Simbadol) is indicated in cats for: Post-operative analgesia (24-hour), Acute pain management (trauma/injury).
These are general warnings for Buprenorphine Transmucosal (Simbadol) across species; consult the cat dosing table above for species-specific guidance. Cats ONLY — not approved for dogs. Single SC injection provides 24-hour pain control. Sedation, decreased appetite, and hyperthermia possible. Do not combine with full mu agonists.
Why a species-specific page? Buprenorphine Transmucosal (Simbadol) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.