Buprenorphine Transmucosal (Simbadol) for Cat
Cat · Felis catus · typical adult weight 2.50–7.00 kg
Buprenorphine Transmucosal (Simbadol) is used in cat for Post-operative analgesia (24-hour), Acute pain management (trauma/injury). Routes documented in cat: SC. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 2 cited dose rules for Buprenorphine Transmucosal (Simbadol) in cat, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Simbadol
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| SC | 0.24 mg/kg | Single SC injection q24h | Single injection provides 24-hour analgesia; repeat once daily if needed up to 3 days | Post-operative analgesia (24-hour) | Strong | Simbadol FDA Product Label; AAFP Pain Management Guidelines |
| SC | 0.24 mg/kg | q24h SC | Up to 3 days; reassess pain and transition to multimodal protocol | Acute pain management (trauma/injury) | Strong | Simbadol FDA Product Label |
Need the exact dose for your patient?
These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
High-concentration buprenorphine providing 24-hour analgesia from a single SC injection. Partial mu-opioid agonist with ceiling effect on respiratory depression.
Side effects & warnings
Cats ONLY — not approved for dogs. Single SC injection provides 24-hour pain control. Sedation, decreased appetite, and hyperthermia possible. Do not combine with full mu agonists.
Species-specific contraindications and adverse-reaction reports for cat may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Miscellaneous drugs with cat dosing
Why a species-specific page? Buprenorphine Transmucosal (Simbadol) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cat — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.