ExoticRx · exoticrx.com/drugs/dantrolene-injectable
US brand names:Dantrium IV, Ryanodex
Dantrolene Injectable is dosed at 1–3.5 mg/kg IV IV push, repeat to clinical effect in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted); Veterinary Anesthesia Textbooks — Plumb's 10th ed (held) printed p.339, Dantrolene monograph spanning p.339-340; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.340, Dantrolene monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Verify against current literature before clinical use.
Directly inhibits calcium release from the sarcoplasmic reticulum by blocking ryanodine receptors, preventing excitation-contraction coupling in skeletal muscle.
Primary treatment for malignant hyperthermia. Mix requires warming and vigorous shaking. Hepatotoxic with chronic oral use. Muscle weakness expected effect.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 1–3.5 mg/kg | IV push, repeat to clinical effect | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted); Veterinary Anesthesia Textbooks — Plumb's 10th ed (held) printed p.339, Dantrolene monograph spanning p.339-340; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.340, Dantrolene monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Cat (Domestic) | IV | 1 mg/kg | single dose | Weak | Plumb's Veterinary Drug Handbook, 10th ed (2023), Dantrolene, corpus p.367 (printed p.340), CATS: '1 mg/kg IV as a single dose was effective in male cats under experimental conditions' (refs 8,9 = Straeter-Knowlen M et al. Urethral pressure response to smooth and skeletal muscle relaxants in anesthetized, adult male cats with naturally acquired urethral obstruction. Am J Vet Res. 1995;56(7):919-923; and Straeter-Knowlen IM et al. Am J Vet Res. 1994;55(12):1739-1744). Corroborated by Papich 4th ed, corpus p.234 (printed p.206): 'To relax the urethra in cats, the most effective dose is 1 mg/kg IV.' — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, ; Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, |
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