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Dantrolene

Dantrium

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Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Neurological

Routes

POIV

Indications

Malignant hyperthermia (emergency)Urethral sphincter spasm

Mechanism of Action

Inhibits calcium release from the sarcoplasmic reticulum via ryanodine receptor blockade, reducing skeletal muscle contraction strength.

Side effects & warnings

Treatment of choice for malignant hyperthermia. Hepatotoxicity with chronic oral use. Muscle weakness. IV form requires large volume reconstitution. Monitor liver function.

Species with Dantrolene dosing data (2 dose rules)

Dog (Domestic)

Species references:All Dog (Domestic) drugs

Evidence levels across 2 dose rules

Weak×1Moderate×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)IV1–5 mg/kgq15 min until effectModeratePlumb's Veterinary Drug Handbook, 9th Ed
Dog (Domestic)PO1–5 mg/kgq8hWeakPlumb's Veterinary Drug Handbook, 9th Ed

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