ExoticRx · exoticrx.com/drugs/dantrolene
US brand names:Dantrium
Dantrolene is dosed at 1–5 mg/kg IV single IV dose in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.339, Dantrolene monograph spanning p.339-340; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Verify against current literature before clinical use.
Inhibits calcium release from the sarcoplasmic reticulum via ryanodine receptor blockade, reducing skeletal muscle contraction strength.
Treatment of choice for malignant hyperthermia. Hepatotoxicity with chronic oral use. Muscle weakness. IV form requires large volume reconstitution. Monitor liver function.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 1–5 mg/kg | single IV dose | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.339, Dantrolene monograph spanning p.339-340; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Dog (Domestic) | PO | 1–5 mg/kg | q8h | Weak | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.367 (2026-08-01). — Plumb's 10th ed (held) printed p.339, Dantrolene monograph spanning p.339-340; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, |
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