Skip to main content

Amantadine

Symmetrel

Calculate dosage
Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Neurological

Routes

PO

Indications

Chronic pain (adjunctive)Chronic pain (NMDA antagonist adjunct)

Mechanism of Action

NMDA receptor antagonist that reduces central sensitization (wind-up pain). Also has dopaminergic and antiviral activity. Used for chronic/neuropathic pain.

Side effects & warnings

Adjunctive analgesic for chronic pain (combine with NSAIDs or gabapentin). CNS excitation at high doses. Renal elimination — adjust in renal disease. GI upset.

Species with Amantadine dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs

Evidence levels across 2 dose rules

Moderate×1Weak×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO3–5 mg/kgq24hModeratePlumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)PO3–5 mg/kgq24hWeakPlumb's Veterinary Drug Handbook, 9th Ed

Upgrade for Full Details

Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.

View Plans

More Neurological drugs

Calculate Dosage for Amantadine