Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Misoprostol Veterinary is dosed at 0.002–0.005 mg/kg PO q8-12h in dogs, per Ward DM, Leib MS, Johnston SA, Marini M. The effect of dosing interval on the efficacy of misoprostol in the prevention of aspirin-induced gastric injury. Journal of Veterinary Internal Medicine. 2003;17(3):282-290. doi:10.1111/j.1939-1676.2003.tb02449.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.924 (2026-08-01).. Misoprostol Veterinary is used in dogs for NSAID-induced GI ulcer prophylaxis, GI ulcer treatment. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Misoprostol Veterinary in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Cytotec Vet
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.002–0.005 mg/kg | q8-12h | Duration of NSAID therapy; continue 2-3 days after NSAID discontinuation | NSAID-induced GI ulcer prophylaxis | Strong | Ward DM, Leib MS, Johnston SA, Marini M. The effect of dosing interval on the efficacy of misoprostol in the prevention of aspirin-induced gastric injury. Journal of Veterinary Internal Medicine. 2003;17(3):282-290. doi:10.1111/j.1939-1676.2003.tb02449.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.924 (2026-08-01). |
| PO | 0.003–0.005 mg/kg | q8h | 4-8 weeks for ulcer healing; combine with sucralfate and PPI | GI ulcer treatment | Moderate | Ward DM, Leib MS, Johnston SA, Marini M. The effect of dosing interval on the efficacy of misoprostol in the prevention of aspirin-induced gastric injury. Journal of Veterinary Internal Medicine. 2003;17(3):282-290. doi:10.1111/j.1939-1676.2003.tb02449.x; Johnston SA, Leib MS, Forrester SD, Marini M. The effect of misoprostol on aspirin-induced gastroduodenal lesions in dogs. Journal of Veterinary Internal Medicine. 1995;9(1):32-38. doi:10.1111/j.1939-1676.1995.tb03269.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.924 (2026-08-01). |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Synthetic prostaglandin E1 analog that replaces protective prostaglandins depleted by NSAIDs. Stimulates mucus and bicarbonate secretion and maintains mucosal blood flow.
ABORTIFACIENT — do not handle if pregnant. Diarrhea common initially. Co-prescribe with chronic NSAID use for GI protection. Do not use in pregnant animals.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Misoprostol Veterinary dose ranges in dogs, with cited source references: PO 0.002–0.005 mg/kg q8-12h; PO 0.003–0.005 mg/kg q8h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Misoprostol Veterinary in dogs: PO.
Cited course lengths for Misoprostol Veterinary in dogs include: Duration of NSAID therapy; continue 2-3 days after NSAID discontinuation; 4-8 weeks for ulcer healing; combine with sucralfate and PPI. Duration depends on the indication — match it to the specific dose rule in the table above.
Misoprostol Veterinary is indicated in dogs for: NSAID-induced GI ulcer prophylaxis, GI ulcer treatment.
These are general warnings for Misoprostol Veterinary across species; consult the dog dosing table above for species-specific guidance. ABORTIFACIENT — do not handle if pregnant. Diarrhea common initially. Co-prescribe with chronic NSAID use for GI protection. Do not use in pregnant animals.
Why a species-specific page? Misoprostol Veterinary pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.