Cat · Felis catus · typical adult weight 2.50–7.00 kg
Chlorpheniramine is dosed at 1–2 mg per cat PO q12h in cats, per Scott DW, Miller WH. The combination of an antihistamine (chlorpheniramine) and an omega-3/omega-6 fatty acid-containing product for the management of pruritic cats - results of an open clinical-trial. N Z Vet J. 1995;43:29-31. doi:10.1080/00480169.1995.35839; Miller W. Nonsteroidal anti-inflammatory agents in the management of canine and feline pruritus. In: Bonagura JD, ed. Current Veterinary Therapy X, Small Animal Practice. 10th ed. WB Saunders; 1989:566-569. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.279 (2026-08-01).. Chlorpheniramine is used in cats for Allergic pruritus, eosinophilic granuloma adjunct. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Chlorpheniramine in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Chlor-Trimeton
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–2 mg per catmax 4 mg total | q12h | Long-term | Allergic pruritus, eosinophilic granuloma adjunct | Moderate | Scott DW, Miller WH. The combination of an antihistamine (chlorpheniramine) and an omega-3/omega-6 fatty acid-containing product for the management of pruritic cats - results of an open clinical-trial. N Z Vet J. 1995;43:29-31. doi:10.1080/00480169.1995.35839; Miller W. Nonsteroidal anti-inflammatory agents in the management of canine and feline pruritus. In: Bonagura JD, ed. Current Veterinary Therapy X, Small Animal Practice. 10th ed. WB Saunders; 1989:566-569. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.279 (2026-08-01). |
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Competitive H1 receptor antagonist. Blocks histamine-mediated allergic responses. Also has mild anticholinergic and sedative properties.
Most commonly used antihistamine in cats. Mild sedation. Ensure product does not contain decongestants. Limited efficacy for pruritus but safe and well-tolerated.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Chlorpheniramine dose range in cats, with cited source references: PO 1–2 mg per cat q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Chlorpheniramine in cats: PO.
Cited course lengths for Chlorpheniramine in cats include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Chlorpheniramine is indicated in cats for: Allergic pruritus, eosinophilic granuloma adjunct.
These are general warnings for Chlorpheniramine across species; consult the cat dosing table above for species-specific guidance. Most commonly used antihistamine in cats. Mild sedation. Ensure product does not contain decongestants. Limited efficacy for pruritus but safe and well-tolerated.
Why a species-specific page? Chlorpheniramine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.