Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Chlorpheniramine is dosed at 0.2–0.5 mg/kg PO q8-12h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.279 (2026-08-01). — Plumb's 10th ed (held) printed p.251, Chlorpheniramine monograph spanning p.251-252; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Chlorpheniramine is used in dogs for Allergic reactions, pruritus. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Chlorpheniramine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Chlor-Trimeton
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.2–0.5 mg/kg | q8-12h | As needed | Allergic reactions, pruritus | Weak | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.279 (2026-08-01). — Plumb's 10th ed (held) printed p.251, Chlorpheniramine monograph spanning p.251-252; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/animal) | Route | Source | As printed |
|---|---|---|---|
| 4–8 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.181 | • 4-8 mg/dog q12h PO; up to a maxi- • 2 mg/cat q12h PO. |
| 2 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.181 | • 4-8 mg/dog q12h PO; up to a maxi- • 2 mg/cat q12h PO. |
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.5 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.181 | mum dose of 0.5 mg/kg q12h. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Competitive H1 receptor antagonist. Blocks histamine-mediated allergic responses. Also has mild anticholinergic and sedative properties.
Most commonly used antihistamine in cats. Mild sedation. Ensure product does not contain decongestants. Limited efficacy for pruritus but safe and well-tolerated.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Chlorpheniramine dose range in dogs, with cited source references: PO 0.2–0.5 mg/kg q8-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Chlorpheniramine in dogs: PO.
Cited course lengths for Chlorpheniramine in dogs include: As needed. Duration depends on the indication — match it to the specific dose rule in the table above.
Chlorpheniramine is indicated in dogs for: Allergic reactions, pruritus.
These are general warnings for Chlorpheniramine across species; consult the dog dosing table above for species-specific guidance. Most commonly used antihistamine in cats. Mild sedation. Ensure product does not contain decongestants. Limited efficacy for pruritus but safe and well-tolerated.
Why a species-specific page? Chlorpheniramine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.