Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Diphenhydramine is used in dog for Acute allergic reaction, pre-chemotherapy, Allergic reactions, motion sickness, mild sedation. Routes documented in dog: IM, PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Diphenhydramine in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Benadryl
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Competitive antagonist at histamine H1 receptors. Also has anticholinergic, anti-motion sickness, and mild sedative properties.
Sedation common (first-generation). Anticholinergic effects (dry mouth, urinary retention). Ensure product does not contain xylitol or pseudoephedrine. Dogs and cats. Less effective than second-gen antihistamines for pruritus.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Diphenhydramine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.