ExoticRx · exoticrx.com/drugs/digestive-enzyme-supplement-pancrelipase
US brand names:Viokase, PanaKare Plus, Creon Vet
Digestive Enzyme Supplement (Pancrelipase) is dosed at 1–2 tsp/20kg/meal PO With each meal in dogs, per Steiner JM. How I Treat--Exocrine Pancreatic Insufficiency. Presented at: WSAVA; 2008. doi:10.18578/bnf.286618066; Bunch S. Hepatobiliary and exocrine pancreatic disorders. In: Small Animal Internal Medicine. 3rd ed. Mosby; 2003:472-567. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1009 (2026-08-01).. Verify against current literature before clinical use.
Porcine-derived lipase, amylase, and protease enzymes that replace deficient pancreatic secretions, enabling digestion and absorption of fats, carbohydrates, and proteins.
Mix with food immediately before feeding. May cause oral ulceration if not mixed well. High doses may cause diarrhea. Enzyme potency varies between products.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 1–2 tsp/20kg/meal | With each meal | Strong | Steiner JM. How I Treat--Exocrine Pancreatic Insufficiency. Presented at: WSAVA; 2008. doi:10.18578/bnf.286618066; Bunch S. Hepatobiliary and exocrine pancreatic disorders. In: Small Animal Internal Medicine. 3rd ed. Mosby; 2003:472-567. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1009 (2026-08-01). |
| Cat (Domestic) | PO | 0.5–1 tsp per meal | With each meal | Strong | Rothrock K. Exocrine Pancreatic Insufficiency. Feline Associate Database; 2011. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1009 (2026-08-01). |
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.