Bird · Ara ararauna · typical adult weight 0.90–1.30 kg
Diphenhydramine is dosed at 2 mg/kg IM, PO q12h in blue-and-gold macaws, per Starkey SR, Morrisey JK, Hickam JD, et al. Extrapyramidal side effects in a blue and gold macaw (Ara ararauna) treated with haloperidol and clomipramine. J Avian Med Surg. 2008;22:234-239. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.472 doi:10.1647/2007-037.1 — Carpenter's Exotic Animal Formulary 6th ed, Table 5.10 (Psychotropic and Antiepileptic Agents Used in Birds.a,b). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Diphenhydramine is used in blue-and-gold macaws for Treatment of extrapyramidal side effects of a haloperidol/clomipramine combination. Routes documented in blue-and-gold macaws: IM, PO. A typical adult blue-and-gold macaw weighs 0.90–1.30 kg. ExoticRx lists 1 cited dose rule for Diphenhydramine in blue-and-gold macaws, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Benadryl
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IM, PO | 2 mg/kg | q12h | Treatment of extrapyramidal side effects of a haloperidol/clomipramine combination | Moderate | Starkey SR, Morrisey JK, Hickam JD, et al. Extrapyramidal side effects in a blue and gold macaw (Ara ararauna) treated with haloperidol and clomipramine. J Avian Med Surg. 2008;22:234-239. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.472 doi:10.1647/2007-037.1 — Carpenter's Exotic Animal Formulary 6th ed, Table 5.10 (Psychotropic and Antiepileptic Agents Used in Birds.a,b). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 2–4 | PO | BSAVA Manual of Psittacine Birds, 2nd edp.314 | 2-4 mg/kg orally q12h | Antihistamine antipruritic and sedative |
| 2–4 | PO | BSAVA Small Animal Formulary, 10th ed — Part B (Exotic Pets)p.122 | 2-4 mg/kg p.o. q12h |
| 2 | IM | Carpenter's Exotic Animal Formulary, 6th edTable 5.10 | 2 mg/kg IM, PO q12h |
| 1–4 | PO | Carpenter's Exotic Animal Formulary, 6th edTable 5.18 | 1-4 mg/kg PO q8-12h,952 |
| 2 | PO |
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These ranges are per kg. Enter your blue-and-gold macaw's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Competitive antagonist at histamine H1 receptors. Also has anticholinergic, anti-motion sickness, and mild sedative properties.
Sedation common (first-generation). Anticholinergic effects (dry mouth, urinary retention). Ensure product does not contain xylitol or pseudoephedrine. Dogs and cats. Less effective than second-gen antihistamines for pruritus.
Species-specific contraindications and adverse-reaction reports for blue-and-gold macaws may differ from canine / feline reference data — consult the primary citations listed with each rule.
Diphenhydramine dose range in blue-and-gold macaws, with cited source references: IM, PO 2 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Diphenhydramine in blue-and-gold macaws: IM, PO.
Diphenhydramine is indicated in blue-and-gold macaws for: Treatment of extrapyramidal side effects of a haloperidol/clomipramine combination.
These are general warnings for Diphenhydramine across species; consult the blue-and-gold macaw dosing table above for species-specific guidance. Sedation common (first-generation). Anticholinergic effects (dry mouth, urinary retention). Ensure product does not contain xylitol or pseudoephedrine. Dogs and cats. Less effective than second-gen antihistamines for pruritus.
Why a species-specific page? Diphenhydramine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in blue-and-gold macaws — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| Carpenter's Exotic Animal Formulary, 6th edTable 5.9 |
| 2 mg/kg PO, IM q12h,892 |
| 2–4 | PO | Carpenter's Exotic Animal Formulary, 6th edTable 5.10 | 2-4 mg/kg PO q12h,952 |
| Dose (mg/l) | Route | Source | As printed |
|---|---|---|---|
| 2 | — | Carpenter's Exotic Animal Formulary, 6th edTable 5.10 | 2 mg/L drinking water,952 |
| 20–40 | — | Carpenter's Exotic Animal Formulary, 6th edTable 5.18 | 20-40 mg/L drinking water |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.