Equine · Equus caballus · typical adult weight 350.00–700.00 kg
Hyaluronic Acid (Equine Injectable) is dosed at 20–40 mg per joint INTRA-ARTICULAR weekly for 3 weeks in horses, per FDA-approved label dosages as reproduced in Plumb's: Hyvisc (hyaluronate sodium), Hyalovet, Legend. Plumb's cites no numbered reference on these label rows. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.634 (2026-08-01).. Hyaluronic Acid (Equine Injectable) is used in horses for Joint inflammation, osteoarthritis, Non-infectious joint dysfunction, Synovitis associated with equine osteoarthritis. Routes documented in horses: INTRA-ARTICULAR, IV. A typical adult horse weighs 350.00–700.00 kg. ExoticRx lists 3 cited dose rules for Hyaluronic Acid (Equine Injectable) in horses, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Legend, Hyalovet
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| INTRA-ARTICULAR | 20–40 mg per joint | weekly for 3 weeks | — | Joint inflammation, osteoarthritis | Strong | FDA-approved label dosages as reproduced in Plumb's: Hyvisc (hyaluronate sodium), Hyalovet, Legend. Plumb's cites no numbered reference on these label rows. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.634 (2026-08-01). |
| IV | 0.008 mg/kg (40mg/horse)max 40 mg total | Weekly | 3 weekly treatments | Non-infectious joint dysfunction | Strong | FDA NADA Label |
| IV | 40 mg total | weekly for 3 weeks | — | Synovitis associated with equine osteoarthritis | Strong | FDA-approved label dosage (Legend, hyaluronate sodium 10 mg/mL, NADA 140-883) as reproduced in Plumb's; NexHA carries the identical 40 mg IV weekly x3 regimen. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.634 (2026-08-01). |
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These ranges are per kg. Enter your horse's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
High molecular weight hyaluronan that restores viscoelastic properties of synovial fluid, inhibits inflammatory mediators, and protects articular cartilage.
IV formulation (Legend) for non-infectious joint dysfunction. Intra-articular injection requires sterile technique. Transient joint effusion may occur with IA injection. Not for use in horses intended for food.
Species-specific contraindications and adverse-reaction reports for horses may differ from canine / feline reference data — consult the primary citations listed with each rule.
Hyaluronic Acid (Equine Injectable) dose ranges in horses, with cited source references: INTRA-ARTICULAR 20–40 mg per joint weekly for 3 weeks; IV 0.008 mg/kg (40mg/horse) Weekly; IV 40 mg total weekly for 3 weeks. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Hyaluronic Acid (Equine Injectable) in horses: INTRA-ARTICULAR, IV.
Cited course lengths for Hyaluronic Acid (Equine Injectable) in horses include: 3 weekly treatments. Duration depends on the indication — match it to the specific dose rule in the table above.
Hyaluronic Acid (Equine Injectable) is indicated in horses for: Joint inflammation, osteoarthritis, Non-infectious joint dysfunction, Synovitis associated with equine osteoarthritis.
These are general warnings for Hyaluronic Acid (Equine Injectable) across species; consult the horse dosing table above for species-specific guidance. IV formulation (Legend) for non-infectious joint dysfunction. Intra-articular injection requires sterile technique. Transient joint effusion may occur with IA injection. Not for use in horses intended for food.
Why a species-specific page? Hyaluronic Acid (Equine Injectable) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in horses — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.