Equine · Equus caballus · typical adult weight 350.00–700.00 kg
Polysulfated Glycosaminoglycan (Equine) is dosed at 500 mg total IM every 4 days in horses, per Adequan I.M.- Polysulfated Glycosaminoglycan Injection, Solution [Package Insert]. American Regent, Inc.; 2019. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1067 (2026-08-01).. Polysulfated Glycosaminoglycan (Equine) is used in horses for Degenerative joint disease. Routes documented in horses: IM. A typical adult horse weighs 350.00–700.00 kg. ExoticRx lists 1 cited dose rule for Polysulfated Glycosaminoglycan (Equine) in horses, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Adequan Equine
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IM | 500 mg total | every 4 days | 7 treatments (28 days) | Degenerative joint disease | Strong | Adequan I.M.- Polysulfated Glycosaminoglycan Injection, Solution [Package Insert]. American Regent, Inc.; 2019. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1067 (2026-08-01). |
Need the exact dose for your patient?
Enter your horse's weight to check these cited ranges in the calculator — unit and concentration math done for you.
Inhibits catabolic enzymes (metalloproteinases, serine proteases) involved in cartilage degradation. Stimulates synovial fluid production and chondrocyte metabolism.
FDA-approved for equine use. Standard protocol: 500mg IM every 4 days for 7 treatments. Not for use in horses intended for food. Mild transient joint effusion may occur.
Species-specific contraindications and adverse-reaction reports for horses may differ from canine / feline reference data — consult the primary citations listed with each rule.
Polysulfated Glycosaminoglycan (Equine) dose range in horses, with cited source references: IM 500 mg total every 4 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Polysulfated Glycosaminoglycan (Equine) in horses: IM.
Cited course lengths for Polysulfated Glycosaminoglycan (Equine) in horses include: 7 treatments (28 days). Duration depends on the indication — match it to the specific dose rule in the table above.
Polysulfated Glycosaminoglycan (Equine) is indicated in horses for: Degenerative joint disease.
These are general warnings for Polysulfated Glycosaminoglycan (Equine) across species; consult the horse dosing table above for species-specific guidance. FDA-approved for equine use. Standard protocol: 500mg IM every 4 days for 7 treatments. Not for use in horses intended for food. Mild transient joint effusion may occur.
Why a species-specific page? Polysulfated Glycosaminoglycan (Equine) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in horses — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.