ExoticRx · exoticrx.com/drugs/hydroxychloroquine-dermatologic
US brand names:Plaquenil
Hydroxychloroquine Dermatologic is dosed at 5–10 mg/kg PO q24h in dogs, per Miller WH, Small Animal Dermatology, 7th Ed. Verify against current literature before clinical use.
Accumulates in lysosomes, raising pH and interfering with antigen processing. Inhibits toll-like receptor signaling and reduces pro-inflammatory cytokine production.
Retinal toxicity with prolonged use — monitor ophthalmic exams. GI upset common. Very limited veterinary use for discoid lupus and other immune-mediated dermatoses.
Species references:All Dog (Domestic) drugs
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