Cat · Felis catus · typical adult weight 2.50–7.00 kg
Leflunomide is dosed at 2–4 mg/kg PO q24h in cats, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.738, Leflunomide monograph spanning p.738-739; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Leflunomide is used in cats for Immune-mediated disease. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Leflunomide in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Arava
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2–4 mg/kg | q24h | Weeks to months | Immune-mediated disease | Weak | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.738, Leflunomide monograph spanning p.738-739; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 2 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.467 | • 2 mg/kg per day, for 2 days, PO, then 2 mg/kg q48h PO. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Inhibits dihydroorotate dehydrogenase blocking de novo pyrimidine synthesis in rapidly dividing lymphocytes. Immunomodulatory.
Used for immune-mediated polyarthritis and other immune-mediated diseases. Hepatotoxic — monitor liver enzymes. Teratogenic. Diarrhea, anorexia. Slow onset (weeks).
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Leflunomide dose range in cats, with cited source references: PO 2–4 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Leflunomide in cats: PO.
Cited course lengths for Leflunomide in cats include: Weeks to months. Duration depends on the indication — match it to the specific dose rule in the table above.
Leflunomide is indicated in cats for: Immune-mediated disease.
These are general warnings for Leflunomide across species; consult the cat dosing table above for species-specific guidance. Used for immune-mediated polyarthritis and other immune-mediated diseases. Hepatotoxic — monitor liver enzymes. Teratogenic. Diarrhea, anorexia. Slow onset (weeks).
Why a species-specific page? Leflunomide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.