Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Methacholine Ophthalmic is used in dog for Dysautonomia diagnosis. Routes documented in dog: TOPICAL (ophthalmic). A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Methacholine Ophthalmic in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Provocholine Ophthalmic
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| TOPICAL (ophthalmic) | 0 1-2 drops per eye | Single application (diagnostic) | Observe for 20-30 minutes | Dysautonomia diagnosis | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Cholinergic agonist that causes pupillary constriction (miosis). Used diagnostically for dysautonomia (Key-Gaskell syndrome) — denervated pupils are supersensitive.
Diagnostic use only. Normal pupils will not respond to dilute solution. Positive response (miosis) indicates denervation supersensitivity.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Methacholine Ophthalmic pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.