Reptile · Eublepharis macularius · typical adult weight 0.04–0.10 kg
Silymarin is dosed at 4–15 mg/kg PO q8-12h in leopard geckos, per 149. Jepson L. Lizards. Exotic Animal Medicine: A Quick Reference Guide. Philadelphia: Saunders/Elsevier; 2009:268-314. — Mined from Mader's Reptile and Amphibian Medicine and Surgery, 3rd Ed, p.1420 (2026-08-01, PENDING REVIEW). Silymarin is used in leopard geckos for Hepatoprotectant. Routes documented in leopard geckos: PO. A typical adult leopard gecko weighs 0.04–0.10 kg. ExoticRx lists 1 cited dose rule for Silymarin in leopard geckos, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Marin, Milk Thistle, Denamarin, Milk Thistle (Silymarin)
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| PO | 4–15 mg/kg | q8-12h | Hepatoprotectant | Weak | 149. Jepson L. Lizards. Exotic Animal Medicine: A Quick Reference Guide. Philadelphia: Saunders/Elsevier; 2009:268-314. — Mined from Mader's Reptile and Amphibian Medicine and Surgery, 3rd Ed, p.1420 (2026-08-01, PENDING REVIEW) |
Need the exact dose for your patient?
These ranges are per kg. Enter your leopard gecko's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Antioxidant and anti-inflammatory flavonoid from milk thistle. Stabilizes hepatocyte membranes, stimulates protein synthesis, and scavenges free radicals.
Generally safe. Often combined with SAMe (Denamarin). Evidence for hepatoprotection moderate. GI upset at high doses. May interact with P-glycoprotein substrates.
Species-specific contraindications and adverse-reaction reports for leopard geckos may differ from canine / feline reference data — consult the primary citations listed with each rule.
Silymarin dose range in leopard geckos, with cited source references: PO 4–15 mg/kg q8-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Silymarin in leopard geckos: PO.
Silymarin is indicated in leopard geckos for: Hepatoprotectant.
These are general warnings for Silymarin across species; consult the leopard gecko dosing table above for species-specific guidance. Generally safe. Often combined with SAMe (Denamarin). Evidence for hepatoprotection moderate. GI upset at high doses. May interact with P-glycoprotein substrates.
Why a species-specific page? Silymarin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in leopard geckos — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.