Livestock · Ovis aries · typical adult weight 30.00–120.00 kg
Tilmicosin is dosed at 10 mg/kg SC single dose in sheep, per MICOTIL 300- Tilmicosin Phosphate Injection [Product Label]. Elanco US Inc.; 2020. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=08f1aecd-33c2-457b-8a45-c38fafb3a1c7 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1268 (2026-08-01). — Plumb's 10th ed (held) printed p.1241, Tilmicosin monograph spanning p.1240-1241; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — 21 CFR § 522.2471 (Tilmicosin), conditions of use for Sheep: 10-10 mg/kg. Related tolerances: 21 CFR § 556.735. Retrieved from the eCFR API, snapshot 2026-01-01. https://www.ecfr.gov/current/title-21/section-522.2471 — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Tilmicosin is used in sheep for Ovine respiratory disease due to Mannheimia haemolytica - sheep greater than 15 kg (33 lb) only (label dosage), Ovine respiratory disease (Mannheimia haemolytica) - sheep over 15 kg (33 lb) only. Routes documented in sheep: SC. A typical adult sheep weighs 30.00–120.00 kg. ExoticRx lists 2 cited dose rules for Tilmicosin in sheep, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Micotil, Pulmotil
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| SC | 10 mg/kg | single dose | — | Ovine respiratory disease due to Mannheimia haemolytica - sheep greater than 15 kg (33 lb) only (label dosage) | Moderate | MICOTIL 300- Tilmicosin Phosphate Injection [Product Label]. Elanco US Inc.; 2020. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=08f1aecd-33c2-457b-8a45-c38fafb3a1c7 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1268 (2026-08-01). — Plumb's 10th ed (held) printed p.1241, Tilmicosin monograph spanning p.1240-1241; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — 21 CFR § 522.2471 (Tilmicosin), conditions of use for Sheep: 10-10 mg/kg. Related tolerances: 21 CFR § 556.735. Retrieved from the eCFR API, snapshot 2026-01-01. https://www.ecfr.gov/current/title-21/section-522.2471 — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| SC | 10 mg/kg | Once | Single injection | Ovine respiratory disease (Mannheimia haemolytica) - sheep over 15 kg (33 lb) only | Moderate | MICOTIL 300- Tilmicosin Phosphate Injection [Product Label]. Elanco US Inc.; 2020. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=08f1aecd-33c2-457b-8a45-c38fafb3a1c7 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1268 (2026-08-01). — Plumb's 10th ed (held) printed p.1241, Tilmicosin monograph spanning p.1240-1241; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — 21 CFR § 522.2471 (Tilmicosin), conditions of use for Sheep: 10-10 mg/kg. Related tolerances: 21 CFR § 556.735. Retrieved from the eCFR API, snapshot 2026-01-01. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 10 | SC | Papich Saunders Handbook of Veterinary Drugs, 4th edp.819 | • 10 mg/kg SQ single dose. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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These ranges are per kg. Enter your sheep's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Semi-synthetic macrolide binding 50S ribosomal subunit. Excellent pulmonary tissue concentration. Bacteriostatic.
FATAL in horses, pigs, and non-human primates — IV injection causes acute cardiac toxicity. Cattle and sheep SC injection only. NOT for use in small animals.
Species-specific contraindications and adverse-reaction reports for sheep may differ from canine / feline reference data — consult the primary citations listed with each rule.
Tilmicosin dose ranges in sheep, with cited source references: SC 10 mg/kg single dose; SC 10 mg/kg Once. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Tilmicosin in sheep: SC.
Cited course lengths for Tilmicosin in sheep include: Single injection. Duration depends on the indication — match it to the specific dose rule in the table above.
Tilmicosin is indicated in sheep for: Ovine respiratory disease due to Mannheimia haemolytica - sheep greater than 15 kg (33 lb) only (label dosage), Ovine respiratory disease (Mannheimia haemolytica) - sheep over 15 kg (33 lb) only.
These are general warnings for Tilmicosin across species; consult the sheep dosing table above for species-specific guidance. FATAL in horses, pigs, and non-human primates — IV injection causes acute cardiac toxicity. Cattle and sheep SC injection only. NOT for use in small animals.
Why a species-specific page? Tilmicosin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in sheep — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.