Pocket Pet · Cavia porcellus · typical adult weight 0.70–1.20 kg
Tramadol is dosed at 5–10 mg/kg PO q12h in guinea pigs, per Hoppes S. Analgesia and anesthesia of rabbits and rodents. Presented at: Southwest Veterinary Symposium; 2016. PMID: 1447903 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1291 (2026-08-01). — Plumb's 10th ed (held) printed p.1261, Tramadol monograph spanning p.1261-1263; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Zoo Animal and Wildlife Immobilization and Anesthesia — ISBN 9780813811833, https://openlibrary.org/isbn/9780813811833. Tramadol is used in guinea pigs for Pain management. Routes documented in guinea pigs: PO. A typical adult guinea pig weighs 0.70–1.20 kg. ExoticRx lists 1 cited dose rule for Tramadol in guinea pigs, drawn from published veterinary references. Verify against current literature before clinical use.
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 5–10 mg/kg | q12h | As needed | Pain management | Extrapolated | Hoppes S. Analgesia and anesthesia of rabbits and rodents. Presented at: Southwest Veterinary Symposium; 2016. PMID: 1447903 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1291 (2026-08-01). — Plumb's 10th ed (held) printed p.1261, Tramadol monograph spanning p.1261-1263; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Zoo Animal and Wildlife Immobilization and Anesthesia — ISBN 9780813811833, https://openlibrary.org/isbn/9780813811833 |
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These ranges are per kg. Enter your guinea pig's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Weak mu-opioid receptor agonist plus norepinephrine and serotonin reuptake inhibition. Dual mechanism of analgesia.
Dogs metabolize to O-desmethyltramadol poorly compared to humans (reduced opioid effect). May cause sedation, dysphoria. Serotonin syndrome risk with concurrent SSRIs. Cats may respond better than dogs.
Species-specific contraindications and adverse-reaction reports for guinea pigs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Tramadol dose range in guinea pigs, with cited source references: PO 5–10 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Tramadol in guinea pigs: PO.
Cited course lengths for Tramadol in guinea pigs include: As needed. Duration depends on the indication — match it to the specific dose rule in the table above.
Tramadol is indicated in guinea pigs for: Pain management.
These are general warnings for Tramadol across species; consult the guinea pig dosing table above for species-specific guidance. Dogs metabolize to O-desmethyltramadol poorly compared to humans (reduced opioid effect). May cause sedation, dysphoria. Serotonin syndrome risk with concurrent SSRIs. Cats may respond better than dogs.
Why a species-specific page? Tramadol pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in guinea pigs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.