Pocket Pet · Cavia porcellus · typical adult weight 0.70–1.20 kg
Xylazine is dosed at 5–10 mg/kg SC, IM, IP not stated (single dose) in guinea pigs, per Mitchell MA, Tully Jr.T.N, eds. Manual of Exotic Pet Practice, Saunders/Elsevier, St. Louis, MO; 2009. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.788 (2026-08-01, PENDING REVIEW). Xylazine is used in guinea pigs for Sedation. Routes documented in guinea pigs: SC, IM, IP. A typical adult guinea pig weighs 0.70–1.20 kg. ExoticRx lists 1 cited dose rule for Xylazine in guinea pigs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Rompun, AnaSed
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| SC, IM, IP | 5–10 mg/kg | not stated (single dose) | Sedation | Weak | Mitchell MA, Tully Jr.T.N, eds. Manual of Exotic Pet Practice, Saunders/Elsevier, St. Louis, MO; 2009. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.788 (2026-08-01, PENDING REVIEW) |
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These ranges are per kg. Enter your guinea pig's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Alpha-2 adrenergic agonist causing dose-dependent sedation, analgesia, and muscle relaxation. Also activates peripheral alpha-2 receptors causing vasoconstriction and bradycardia.
Profound bradycardia and vomiting (especially cats). Cats more sensitive than dogs. Reversible with atipamezole or yohimbine. Avoid in horses with colic (ileus). 100mg/ml for large animals only.
Species-specific contraindications and adverse-reaction reports for guinea pigs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Xylazine dose range in guinea pigs, with cited source references: SC, IM, IP 5–10 mg/kg not stated (single dose). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Xylazine in guinea pigs: SC, IM, IP.
Xylazine is indicated in guinea pigs for: Sedation.
These are general warnings for Xylazine across species; consult the guinea pig dosing table above for species-specific guidance. Profound bradycardia and vomiting (especially cats). Cats more sensitive than dogs. Reversible with atipamezole or yohimbine. Avoid in horses with colic (ileus). 100mg/ml for large animals only.
Why a species-specific page? Xylazine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in guinea pigs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.