Pocket Pet · Mus musculus · typical adult weight 0.02–0.04 kg
Xylazine is dosed at 10 mg/kg IP Once (induction), w/ ketamine 100 mg/kg IP in mice, per Beecy S, Meuse D, Kizielewicz N, Beale C, Molk D. Optimization of Ketamine/Xylazine Anesthesia in Geriatric Mice. J Am Assoc Lab Anim Sci. 2025;64(4):778-787. doi:10.30802/AALAS-JAALAS-25-010. PMID 40683626. https://pmc.ncbi.nlm.nih.gov/articles/PMC12530262/. Xylazine is used in mice for Injectable general anaesthesia (with ketamine), Sedation (alpha-2 agonist). Routes documented in mice: IP, SC, IM, IP. A typical adult mouse weighs 0.02–0.04 kg. ExoticRx lists 2 cited dose rules for Xylazine in mice, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Rompun, AnaSed
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IP | 10 mg/kg | Once (induction), w/ ketamine 100 mg/kg IP | Injectable general anaesthesia (with ketamine) | Moderate | Beecy S, Meuse D, Kizielewicz N, Beale C, Molk D. Optimization of Ketamine/Xylazine Anesthesia in Geriatric Mice. J Am Assoc Lab Anim Sci. 2025;64(4):778-787. doi:10.30802/AALAS-JAALAS-25-010. PMID 40683626. https://pmc.ncbi.nlm.nih.gov/articles/PMC12530262/ |
| SC, IM, IP | 5–10 mg/kg | once | Sedation (alpha-2 agonist) | Moderate | 127. Mitchell MA, Tully Jr.T.N, eds. Manual of Exotic Pet Practice, Saunders/Elsevier, St. Louis, MO; 2009. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.788 (2026-08-01, PENDING REVIEW) |
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These ranges are per kg. Enter your mouse's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Alpha-2 adrenergic agonist causing dose-dependent sedation, analgesia, and muscle relaxation. Also activates peripheral alpha-2 receptors causing vasoconstriction and bradycardia.
Profound bradycardia and vomiting (especially cats). Cats more sensitive than dogs. Reversible with atipamezole or yohimbine. Avoid in horses with colic (ileus). 100mg/ml for large animals only.
Species-specific contraindications and adverse-reaction reports for mice may differ from canine / feline reference data — consult the primary citations listed with each rule.
Xylazine dose ranges in mice, with cited source references: IP 10 mg/kg Once (induction), w/ ketamine 100 mg/kg IP; SC, IM, IP 5–10 mg/kg once. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Xylazine in mice: IP, SC, IM, IP.
Xylazine is indicated in mice for: Injectable general anaesthesia (with ketamine), Sedation (alpha-2 agonist).
These are general warnings for Xylazine across species; consult the mouse dosing table above for species-specific guidance. Profound bradycardia and vomiting (especially cats). Cats more sensitive than dogs. Reversible with atipamezole or yohimbine. Avoid in horses with colic (ileus). 100mg/ml for large animals only.
Why a species-specific page? Xylazine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in mice — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.