Cat · Felis catus · typical adult weight 2.50–7.00 kg
Alendronate is dosed at 10 mg per cat PO Once weekly in cats, per Hardy BT, Galvao JFD, Green TA, et al. Treatment of Ionized Hypercalcemia in 12 Cats (2006-2008) Using PO-Administered Alendronate. Journal of Veterinary Internal Medicine. 2015;29(1):200-206. doi:10.1111/jvim.12507 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.55 (2026-08-01).. Alendronate is used in cats for Idiopathic hypercalcemia. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Alendronate in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Fosamax
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 10 mg per catmax 10 mg total | Once weekly | Long-term; monitor ionized calcium q2-4 weeks initially | Idiopathic hypercalcemia | Moderate | Hardy BT, Galvao JFD, Green TA, et al. Treatment of Ionized Hypercalcemia in 12 Cats (2006-2008) Using PO-Administered Alendronate. Journal of Veterinary Internal Medicine. 2015;29(1):200-206. doi:10.1111/jvim.12507 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.55 (2026-08-01). |
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Nitrogen-containing bisphosphonate that inhibits osteoclast-mediated bone resorption by binding to hydroxyapatite and inducing osteoclast apoptosis.
Esophageal irritation risk — give with water, keep upright. May cause jaw osteonecrosis rarely. Used in cats for idiopathic hypercalcemia.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Alendronate dose range in cats, with cited source references: PO 10 mg per cat Once weekly. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Alendronate in cats: PO.
Cited course lengths for Alendronate in cats include: Long-term; monitor ionized calcium q2-4 weeks initially. Duration depends on the indication — match it to the specific dose rule in the table above.
Alendronate is indicated in cats for: Idiopathic hypercalcemia.
These are general warnings for Alendronate across species; consult the cat dosing table above for species-specific guidance. Esophageal irritation risk — give with water, keep upright. May cause jaw osteonecrosis rarely. Used in cats for idiopathic hypercalcemia.
Why a species-specific page? Alendronate pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.