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Clodronate

Osphos

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Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Endocrine

Routes

IM

Indications

Bone painosteolytic lesionspathological bone resorption

Mechanism of Action

Inhibits osteoclast-mediated bone resorption by being incorporated into ATP analogs that are cytotoxic to osteoclasts. Reduces pathological bone remodeling and associated pain.

Side effects & warnings

FDA-approved for horses with navicular syndrome. Renal toxicity possible at high doses. May cause GI signs, colic, or transient discomfort post-injection. Limited small animal data.

Species with Clodronate dosing data (1 dose rule)

Dog (Domestic)

Species references:All Dog (Domestic) drugs

Evidence levels across 1 dose rule

Weak×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

  • · JAVMA; FDA openFDA Adverse Event Database

Sample dosing (1 of 1 cited rule)

A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)SC20–25 mg/kgSingle dose or monthlyWeakJAVMA; FDA openFDA Adverse Event Database

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