ExoticRx · exoticrx.com/drugs/clodronate
US brand names:Osphos
Clodronate is dosed at 20–25 mg/kg SC Single dose or monthly in dogs, per JAVMA; FDA openFDA Adverse Event Database. Verify against current literature before clinical use.
Inhibits osteoclast-mediated bone resorption by being incorporated into ATP analogs that are cytotoxic to osteoclasts. Reduces pathological bone remodeling and associated pain.
FDA-approved for horses with navicular syndrome. Renal toxicity possible at high doses. May cause GI signs, colic, or transient discomfort post-injection. Limited small animal data.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | SC | 20–25 mg/kg | Single dose or monthly | Weak | JAVMA; FDA openFDA Adverse Event Database |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.