Cloprostenol for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Cloprostenol is used in dog for Open pyometra, pregnancy termination. Routes documented in dog: IM. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Cloprostenol in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Estrumate
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IM | 0.001–0.003 mg/kg | q24-48h | 3-5 doses | Open pyometra, pregnancy termination | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Synthetic prostaglandin F2α analog causing luteolysis (destruction of corpus luteum). Much more potent than natural PGF2α.
Side effects & warnings
Handle with extreme caution — can cause abortion in pregnant women through skin absorption. Wear gloves. Bronchoconstriction risk in asthmatic handlers.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Endocrine drugs with dog dosing
Why a species-specific page? Cloprostenol pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.