Livestock · Bos taurus · typical adult weight 250.00–900.00 kg
Closantel (Livestock) is dosed at 10 mg/kg PO Once in cattle, per Michiels M, Meuldermans W, Heykants J. (1987). The metabolism and fate of closantel (Flukiver) in sheep and cattle. Drug Metabol Rev. 18, 235-251. doi:10.3109/03602538708998307 — Verified against Riviere & Papich, Veterinary Pharmacology and Therapeutics, 10th Ed, p.1114 (2026-08-01). — SOURCE UNVERIFIABLE 2026-08-07: the cited book (Papich, Saunders Handbook of Veterinary Drugs (held: 4th ed, 2016)) does not contain this drug anywhere in the held copy. The reference cannot be confirmed here and the page, if any, is unchecked. It is deliberately NOT re-pointed at another text that does mention the molecule — that would assert a provenance this dose never had. Confirm against the source directly before use. — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855; Veterinary Pharmacology and Therapeutics — ISBN 9781118855829, https://openlibrary.org/isbn/9781118855829. Closantel (Livestock) is used in cattle for Haemonchus, liver flukes. Routes documented in cattle: PO. A typical adult cattle weighs 250.00–900.00 kg. ExoticRx lists 1 cited dose rule for Closantel (Livestock) in cattle, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Flukiver, Seponver
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 10 mg/kg | Once | Single dose | Haemonchus, liver flukes | Moderate | Michiels M, Meuldermans W, Heykants J. (1987). The metabolism and fate of closantel (Flukiver) in sheep and cattle. Drug Metabol Rev. 18, 235-251. doi:10.3109/03602538708998307 — Verified against Riviere & Papich, Veterinary Pharmacology and Therapeutics, 10th Ed, p.1114 (2026-08-01). — SOURCE UNVERIFIABLE 2026-08-07: the cited book (Papich, Saunders Handbook of Veterinary Drugs (held: 4th ed, 2016)) does not contain this drug anywhere in the held copy. The reference cannot be confirmed here and the page, if any, is unchecked. It is deliberately NOT re-pointed at another text that does mention the molecule — that would assert a provenance this dose never had. Confirm against the source directly before use. — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855; Veterinary Pharmacology and Therapeutics — ISBN 9781118855829, https://openlibrary.org/isbn/9781118855829 |
Need the exact dose for your patient?
These ranges are per kg. Enter your cattle's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Salicylanilide anthelmintic that uncouples oxidative phosphorylation in the parasite mitochondria. Highly protein-bound with long duration of activity. Effective against Haemonchus and liver flukes.
For cattle and sheep. Effective against adult liver flukes and Haemonchus contortus. Long withdrawal period due to protein binding. Overdose can cause blindness (optic nerve damage). Not available in all markets.
Species-specific contraindications and adverse-reaction reports for cattle may differ from canine / feline reference data — consult the primary citations listed with each rule.
Closantel (Livestock) dose range in cattle, with cited source references: PO 10 mg/kg Once. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Closantel (Livestock) in cattle: PO.
Cited course lengths for Closantel (Livestock) in cattle include: Single dose. Duration depends on the indication — match it to the specific dose rule in the table above.
Closantel (Livestock) is indicated in cattle for: Haemonchus, liver flukes.
These are general warnings for Closantel (Livestock) across species; consult the cattle dosing table above for species-specific guidance. For cattle and sheep. Effective against adult liver flukes and Haemonchus contortus. Long withdrawal period due to protein binding. Overdose can cause blindness (optic nerve damage). Not available in all markets.
Why a species-specific page? Closantel (Livestock) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cattle — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.