Livestock · Bos taurus · typical adult weight 250.00–900.00 kg
Closantel (Livestock) is dosed at 10 mg/kg PO Once in cattle, per Michiels M, Meuldermans W, Heykants J. (1987). The metabolism and fate of closantel (Flukiver) in sheep and cattle. Drug Metabol Rev. 18, 235-251. doi:10.3109/03602538708998307 — Verified against Riviere & Papich, Veterinary Pharmacology and Therapeutics, 10th Ed, p.1114 (2026-08-01).. Closantel (Livestock) is used in cattle for Haemonchus, liver flukes, Liver flukes (Fasciola). Routes documented in cattle: PO, SC. A typical adult cattle weighs 250.00–900.00 kg. ExoticRx lists 2 cited dose rules for Closantel (Livestock) in cattle, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Flukiver, Seponver
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 10 mg/kg | Once | Single dose | Haemonchus, liver flukes | Moderate | Michiels M, Meuldermans W, Heykants J. (1987). The metabolism and fate of closantel (Flukiver) in sheep and cattle. Drug Metabol Rev. 18, 235-251. doi:10.3109/03602538708998307 — Verified against Riviere & Papich, Veterinary Pharmacology and Therapeutics, 10th Ed, p.1114 (2026-08-01). |
| SC | 5–10 mg/kg | single dose | — | Liver flukes (Fasciola) | Moderate | Merck Veterinary Manual |
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These ranges are per kg. Enter your cattle's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Salicylanilide anthelmintic that uncouples oxidative phosphorylation in the parasite mitochondria. Highly protein-bound with long duration of activity. Effective against Haemonchus and liver flukes.
For cattle and sheep. Effective against adult liver flukes and Haemonchus contortus. Long withdrawal period due to protein binding. Overdose can cause blindness (optic nerve damage). Not available in all markets.
Species-specific contraindications and adverse-reaction reports for cattle may differ from canine / feline reference data — consult the primary citations listed with each rule.
Closantel (Livestock) dose ranges in cattle, with cited source references: PO 10 mg/kg Once; SC 5–10 mg/kg single dose. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Closantel (Livestock) in cattle: PO, SC.
Cited course lengths for Closantel (Livestock) in cattle include: Single dose. Duration depends on the indication — match it to the specific dose rule in the table above.
Closantel (Livestock) is indicated in cattle for: Haemonchus, liver flukes, Liver flukes (Fasciola).
These are general warnings for Closantel (Livestock) across species; consult the cattle dosing table above for species-specific guidance. For cattle and sheep. Effective against adult liver flukes and Haemonchus contortus. Long withdrawal period due to protein binding. Overdose can cause blindness (optic nerve damage). Not available in all markets.
Why a species-specific page? Closantel (Livestock) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cattle — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.