Livestock · Bos taurus · typical adult weight 250.00–900.00 kg
Ivermectin is dosed at 0.2 mg/kg PO single dose in cattle, per US FDA. Ivomec Cattle Paste 0.153% (ivermectin), NADA 137-006, Boehringer Ingelheim. https://animaldrugsatfda.fda.gov/adafda/app/search/public/retrievePreviewBean/2012 - cattle (beef; dairy not of breeding age); 23 mg per 250 lb BW (0.2 mg/kg) orally; meat 24 d; no milk withdrawal established. — 21 CFR § 522.1192 (Ivermectin), conditions of use for Cattle: 0.2-0.2 mg/kg. Related tolerances: 21 CFR § 556.344. Retrieved from the eCFR API, snapshot 2026-01-01. https://www.ecfr.gov/current/title-21/section-522.1192. Ivermectin is used in cattle for GI nematodes, lungworms, Internal and external parasites. Routes documented in cattle: PO, SC. A typical adult cattle weighs 250.00–900.00 kg. ExoticRx lists 2 cited dose rules for Ivermectin in cattle, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Ivomec, Heartgard
Contraindicated in Tortoise / Turtle
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| PO | 0.2 mg/kg | single dose | GI nematodes, lungworms | Strong | US FDA. Ivomec Cattle Paste 0.153% (ivermectin), NADA 137-006, Boehringer Ingelheim. https://animaldrugsatfda.fda.gov/adafda/app/search/public/retrievePreviewBean/2012 - cattle (beef; dairy not of breeding age); 23 mg per 250 lb BW (0.2 mg/kg) orally; meat 24 d; no milk withdrawal established. — 21 CFR § 522.1192 (Ivermectin), conditions of use for Cattle: 0.2-0.2 mg/kg. Related tolerances: 21 CFR § 556.344. Retrieved from the eCFR API, snapshot 2026-01-01. https://www.ecfr.gov/current/title-21/section-522.1192 |
| SC | 0.2 mg/kg | single dose | Internal and external parasites | Strong | Ivomec® 1% Injection for Cattle and Swine [Product Label]. Merial; 2010. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.739 (2026-08-01). — Plumb's 10th ed (held) printed p.709, Ivermectin monograph spanning p.709-713; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — 21 CFR § 522.1192 (Ivermectin), conditions of use for Cattle: 0.2-0.2 mg/kg. Related tolerances: 21 CFR § 556.344. Retrieved from the eCFR API, snapshot 2026-01-01. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 5.7–13.8 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.451 | • Slow-release bolus: 5.7-13.8 mg/kg, as a single dose, which has a duration of |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Potentiates glutamate-gated chloride channels in invertebrate nerve and muscle cells, causing paralysis and death of parasites.
TOXIC to MDR1-mutant dogs (Collies, Shelties, Aussies) at elevated doses. DO NOT use in chelonians (turtles/tortoises). Narrow safety margin in some species. Test MDR1 status before use in herding breeds.
Species-specific contraindications and adverse-reaction reports for cattle may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ivermectin dose ranges in cattle, with cited source references: PO 0.2 mg/kg single dose; SC 0.2 mg/kg single dose. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ivermectin in cattle: PO, SC.
Ivermectin is indicated in cattle for: GI nematodes, lungworms, Internal and external parasites.
These are general warnings for Ivermectin across species; consult the cattle dosing table above for species-specific guidance. TOXIC to MDR1-mutant dogs (Collies, Shelties, Aussies) at elevated doses. DO NOT use in chelonians (turtles/tortoises). Narrow safety margin in some species. Test MDR1 status before use in herding breeds.
Why a species-specific page? Ivermectin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cattle — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.