ExoticRx · exoticrx.com/drugs/esafoxolaner
Esafoxolaner is dosed at Dose as printed in that source: 'For topical use in cats only.' Apply 'the minimum dose of 0.055 mL/lb (0.12 mL/kg), which delivers a minimum dose of 0.65 mg/lb (1.44 mg/kg) esafoxolaner, 0.22 mg/lb (0.48 mg/kg) eprinomectin, and 4.53 mg/lb (9.98 mg/kg) praziquantel'; applied topically to the skin of the neck once monthly; for cats and kittens 8 weeks of age and older weighing 1.8 lbs or greater in cats, per NEXGARD COMBO (esafoxolaner, eprinomectin and praziquantel) topical solution for cats — FDA Prescription Animal Drug Label, NADA 141-570, Boehringer Ingelheim Animal Health USA https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=48dd3eaa-18e3-430d-ad40-a964b591fb16. Verify against current literature before clinical use.
Novel isoxazoline blocking GABA and glutamate-gated chloride channels in arthropods. Used in cats for flea, tick, and mite control.
For cats only (NexGard Combo). Combined with eprinomectin and praziquantel. Do not use in kittens <8 weeks or <0.8kg.
Species references:All Cat (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | Topical | Dose as printed in that source: 'For topical use in cats only.' Apply 'the minimum dose of 0.055 mL/lb (0.12 mL/kg), which delivers a minimum dose of 0.65 mg/lb (1.44 mg/kg) esafoxolaner, 0.22 mg/lb (0.48 mg/kg) eprinomectin, and 4.53 mg/lb (9.98 mg/kg) praziquantel'; applied topically to the skin of the neck once monthly; for cats and kittens 8 weeks of age and older weighing 1.8 lbs or greater | q30 days | Strong | NEXGARD COMBO (esafoxolaner, eprinomectin and praziquantel) topical solution for cats — FDA Prescription Animal Drug Label, NADA 141-570, Boehringer Ingelheim Animal Health USA https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=48dd3eaa-18e3-430d-ad40-a964b591fb16 |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.