ExoticRx · exoticrx.com/drugs/afoxolaner-milbemycin-oxime
Afoxolaner-Milbemycin Oxime
NexGard Spectra
Drug Class
Routes
Indications
Mechanism of Action
Afoxolaner (isoxazoline) blocks GABA/glutamate channels in ectoparasites; milbemycin oxime targets glutamate-gated chloride channels in nematodes. Monthly flea/tick/heartworm/dewormer.
Side effects & warnings
Dogs only. Seizure history caution (isoxazoline class). Do not use in dogs <8 weeks or <2 kg. Monthly oral. Available outside US (not FDA-approved combo in US).
Species with Afoxolaner-Milbemycin Oxime dosing data (1 dose rule)
Species references:All Dog (Domestic) drugs
Evidence levels across 1 dose rule
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Backed by a published source
- · BSAVA Small Animal Formulary, 10th Ed
Sample dosing (1 of 1 cited rule)
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0 per label | q30 days | Strong | BSAVA Small Animal Formulary, 10th Ed |
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Source citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.