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Afoxolaner-Milbemycin Oxime

NexGard Spectra

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Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Antiparasitic

Routes

PO

Indications

Fleasheartwormintestinal parasitesticks

Mechanism of Action

Afoxolaner (isoxazoline) blocks GABA/glutamate channels in ectoparasites; milbemycin oxime targets glutamate-gated chloride channels in nematodes. Monthly flea/tick/heartworm/dewormer.

Side effects & warnings

Dogs only. Seizure history caution (isoxazoline class). Do not use in dogs <8 weeks or <2 kg. Monthly oral. Available outside US (not FDA-approved combo in US).

Species with Afoxolaner-Milbemycin Oxime dosing data (1 dose rule)

Species references:All Dog (Domestic) drugs

Evidence levels across 1 dose rule

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

  • · BSAVA Small Animal Formulary, 10th Ed

Sample dosing (1 of 1 cited rule)

A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO0 per labelq30 daysStrongBSAVA Small Animal Formulary, 10th Ed

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