ExoticRx · exoticrx.com/drugs/afoxolaner-milbemycin-oxime
US brand names:NexGard Spectra
Afoxolaner (isoxazoline) blocks GABA/glutamate channels in ectoparasites; milbemycin oxime targets glutamate-gated chloride channels in nematodes. Monthly flea/tick/heartworm/dewormer.
Dogs only. Seizure history caution (isoxazoline class). Do not use in dogs <8 weeks or <2 kg. Monthly oral. Available outside US (not FDA-approved combo in US).
Species references:All Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | Dosing: weight-based chewable | q30 days | Strong | Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.23 (2026-08-01). |
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.