Afoxolaner-Milbemycin Oxime for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Afoxolaner-Milbemycin Oxime is used in dog for Fleas, ticks, heartworm, intestinal parasites. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Afoxolaner-Milbemycin Oxime in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: NexGard Spectra
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0 per label | q30 days | Monthly, year-round | Fleas, ticks, heartworm, intestinal parasites | Strong | BSAVA Small Animal Formulary, 10th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Afoxolaner (isoxazoline) blocks GABA/glutamate channels in ectoparasites; milbemycin oxime targets glutamate-gated chloride channels in nematodes. Monthly flea/tick/heartworm/dewormer.
Side effects & warnings
Dogs only. Seizure history caution (isoxazoline class). Do not use in dogs <8 weeks or <2 kg. Monthly oral. Available outside US (not FDA-approved combo in US).
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Antiparasitic drugs with dog dosing
Why a species-specific page? Afoxolaner-Milbemycin Oxime pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.