Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Afoxolaner-Milbemycin Oxime is used in dogs for Fleas, ticks, heartworm, intestinal parasites. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Afoxolaner-Milbemycin Oxime in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: NexGard Spectra
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | Dosing: weight-based chewable | q30 days | Monthly, year-round | Fleas, ticks, heartworm, intestinal parasites | Strong | Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.23 (2026-08-01). |
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Afoxolaner (isoxazoline) blocks GABA/glutamate channels in ectoparasites; milbemycin oxime targets glutamate-gated chloride channels in nematodes. Monthly flea/tick/heartworm/dewormer.
Dogs only. Seizure history caution (isoxazoline class). Do not use in dogs <8 weeks or <2 kg. Monthly oral. Available outside US (not FDA-approved combo in US).
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Afoxolaner-Milbemycin Oxime dose range in dogs, with cited source references: PO Dosing: weight-based chewable q30 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Afoxolaner-Milbemycin Oxime in dogs: PO.
Cited course lengths for Afoxolaner-Milbemycin Oxime in dogs include: Monthly, year-round. Duration depends on the indication — match it to the specific dose rule in the table above.
Afoxolaner-Milbemycin Oxime is indicated in dogs for: Fleas, ticks, heartworm, intestinal parasites.
These are general warnings for Afoxolaner-Milbemycin Oxime across species; consult the dog dosing table above for species-specific guidance. Dogs only. Seizure history caution (isoxazoline class). Do not use in dogs <8 weeks or <2 kg. Monthly oral. Available outside US (not FDA-approved combo in US).
Why a species-specific page? Afoxolaner-Milbemycin Oxime pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.