Afoxolaner for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Afoxolaner is used in dog for Flea and tick prevention. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Afoxolaner in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: NexGard
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2.5–6.3 mg/kg | q30 days | Monthly | Flea and tick prevention | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Isoxazoline ectoparasiticide blocking GABA and glutamate-gated chloride channels in arthropods. Monthly flea and tick protection.
Side effects & warnings
FDA-approved for dogs. Seizure potential in dogs with neurologic history. Not for use in puppies <8 weeks or <1.8kg. Dogs only (not cats).
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Antiparasitic drugs with dog dosing
Why a species-specific page? Afoxolaner pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.