Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Afoxolaner is dosed at 2.5–6.3 mg/kg PO q30 days in dogs, per Nexgard - Afoxolaner Tablet, Chewable [US Product Label for Dogs]. Boehringer Ingelheim; 2020. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=48dd3eaa-18e3-430d-ad40-a964b591fb16 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.44 (2026-08-01).. Afoxolaner is used in dogs for Flea and tick prevention. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Afoxolaner in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: NexGard
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2.5–6.3 mg/kg | q30 days | Monthly | Flea and tick prevention | Strong | Nexgard - Afoxolaner Tablet, Chewable [US Product Label for Dogs]. Boehringer Ingelheim; 2020. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=48dd3eaa-18e3-430d-ad40-a964b591fb16 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.44 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Isoxazoline ectoparasiticide blocking GABA and glutamate-gated chloride channels in arthropods. Monthly flea and tick protection.
FDA-approved for dogs. Seizure potential in dogs with neurologic history. Not for use in puppies <8 weeks or <1.8kg. Dogs only (not cats).
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Afoxolaner dose range in dogs, with cited source references: PO 2.5–6.3 mg/kg q30 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Afoxolaner in dogs: PO.
Cited course lengths for Afoxolaner in dogs include: Monthly. Duration depends on the indication — match it to the specific dose rule in the table above.
Afoxolaner is indicated in dogs for: Flea and tick prevention.
These are general warnings for Afoxolaner across species; consult the dog dosing table above for species-specific guidance. FDA-approved for dogs. Seizure potential in dogs with neurologic history. Not for use in puppies <8 weeks or <1.8kg. Dogs only (not cats).
Why a species-specific page? Afoxolaner pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.