Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Afoxolaner is dosed at 2.5–6.3 mg/kg PO q30 days in dogs, per Nexgard - Afoxolaner Tablet, Chewable [US Product Label for Dogs]. Boehringer Ingelheim; 2020. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=48dd3eaa-18e3-430d-ad40-a964b591fb16 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.44 (2026-08-01). — Plumb's 10th ed (held) printed p.16, Afoxolaner monograph spanning p.16-17; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Afoxolaner is used in dogs for Flea and tick prevention. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Afoxolaner in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: NexGard
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2.5–6.3 mg/kg | q30 days | Monthly | Flea and tick prevention | Strong | Nexgard - Afoxolaner Tablet, Chewable [US Product Label for Dogs]. Boehringer Ingelheim; 2020. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=48dd3eaa-18e3-430d-ad40-a964b591fb16 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.44 (2026-08-01). — Plumb's 10th ed (held) printed p.16, Afoxolaner monograph spanning p.16-17; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 2.5–6.9 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.23 | Administer monthly. The tablets supply 2.5-6.9 mg/kg of afoxolaner |
| 2.5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.39 | • 2.5 mg/kg (1.14 mg/lb, PO, once per month during flea and tick season). |
| Dose (mg/lb) | Route | Source | As printed |
|---|---|---|---|
| 1.14 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.39 | • 2.5 mg/kg (1.14 mg/lb, PO, once per month during flea and tick season). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Isoxazoline ectoparasiticide blocking GABA and glutamate-gated chloride channels in arthropods. Monthly flea and tick protection.
FDA-approved for dogs. Seizure potential in dogs with neurologic history. Not for use in puppies <8 weeks or <1.8kg. Dogs only (not cats).
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Afoxolaner dose range in dogs, with cited source references: PO 2.5–6.3 mg/kg q30 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Afoxolaner in dogs: PO.
Cited course lengths for Afoxolaner in dogs include: Monthly. Duration depends on the indication — match it to the specific dose rule in the table above.
Afoxolaner is indicated in dogs for: Flea and tick prevention.
These are general warnings for Afoxolaner across species; consult the dog dosing table above for species-specific guidance. FDA-approved for dogs. Seizure potential in dogs with neurologic history. Not for use in puppies <8 weeks or <1.8kg. Dogs only (not cats).
Why a species-specific page? Afoxolaner pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.