Cat · Felis catus · typical adult weight 2.50–7.00 kg
Esafoxolaner is dosed at Dose as printed in that source: 'For topical use in cats only.' Apply 'the minimum dose of 0.055 mL/lb (0.12 mL/kg), which delivers a minimum dose of 0.65 mg/lb (1.44 mg/kg) esafoxolaner, 0.22 mg/lb (0.48 mg/kg) eprinomectin, and 4.53 mg/lb (9.98 mg/kg) praziquantel'; applied topically to the skin of the neck once monthly; for cats and kittens 8 weeks of age and older weighing 1.8 lbs or greater in cats, per NEXGARD COMBO (esafoxolaner, eprinomectin and praziquantel) topical solution for cats — FDA Prescription Animal Drug Label, NADA 141-570, Boehringer Ingelheim Animal Health USA https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=48dd3eaa-18e3-430d-ad40-a964b591fb16. Esafoxolaner is used in cats for Flea, tick, and worm prevention. Routes documented in cats: Topical. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Esafoxolaner in cats, drawn from published veterinary references. Verify against current literature before clinical use.
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| Topical | Dose as printed in that source: 'For topical use in cats only.' Apply 'the minimum dose of 0.055 mL/lb (0.12 mL/kg), which delivers a minimum dose of 0.65 mg/lb (1.44 mg/kg) esafoxolaner, 0.22 mg/lb (0.48 mg/kg) eprinomectin, and 4.53 mg/lb (9.98 mg/kg) praziquantel'; applied topically to the skin of the neck once monthly; for cats and kittens 8 weeks of age and older weighing 1.8 lbs or greater |
| q30 days |
| Monthly |
| Flea, tick, and worm prevention |
| Strong |
| NEXGARD COMBO (esafoxolaner, eprinomectin and praziquantel) topical solution for cats — FDA Prescription Animal Drug Label, NADA 141-570, Boehringer Ingelheim Animal Health USA https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=48dd3eaa-18e3-430d-ad40-a964b591fb16 |
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Novel isoxazoline blocking GABA and glutamate-gated chloride channels in arthropods. Used in cats for flea, tick, and mite control.
For cats only (NexGard Combo). Combined with eprinomectin and praziquantel. Do not use in kittens <8 weeks or <0.8kg.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Esafoxolaner dose range in cats, with cited source references: Topical Dose as printed in that source: 'For topical use in cats only.' Apply 'the minimum dose of 0.055 mL/lb (0.12 mL/kg), which delivers a minimum dose of 0.65 mg/lb (1.44 mg/kg) esafoxolaner, 0.22 mg/lb (0.48 mg/kg) eprinomectin, and 4.53 mg/lb (9.98 mg/kg) praziquantel'; applied topically to the skin of the neck once monthly; for cats and kittens 8 weeks of age and older weighing 1.8 lbs or greater q30 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Esafoxolaner in cats: Topical.
Cited course lengths for Esafoxolaner in cats include: Monthly. Duration depends on the indication — match it to the specific dose rule in the table above.
Esafoxolaner is indicated in cats for: Flea, tick, and worm prevention.
These are general warnings for Esafoxolaner across species; consult the cat dosing table above for species-specific guidance. For cats only (NexGard Combo). Combined with eprinomectin and praziquantel. Do not use in kittens <8 weeks or <0.8kg.
Why a species-specific page? Esafoxolaner pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.