Cat · Felis catus · typical adult weight 2.50–7.00 kg
Esafoxolaner-Eprinomectin-Praziquantel is dosed at Dose as printed in that source: 'For topical use in cats only.' 'the minimum dose of 0.055 mL/lb (0.12 mL/kg), which delivers a minimum dose of 0.65 mg/lb (1.44 mg/kg) esafoxolaner, 0.22 mg/lb (0.48 mg/kg) eprinomectin, and 4.53 mg/lb (9.98 mg/kg) praziquantel'; topical to the skin on the neck, once monthly; cats and kittens 8 weeks of age and older, weighing 1.8 lbs or greater in cats, per NEXGARD COMBO (esafoxolaner, eprinomectin and praziquantel) topical solution for cats — FDA Prescription Animal Drug Label, NADA 141-570, Boehringer Ingelheim Animal Health USA https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=48dd3eaa-18e3-430d-ad40-a964b591fb16. Esafoxolaner-Eprinomectin-Praziquantel is used in cats for Fleas, ticks, heartworm, roundworms, hookworms, tapeworms. Routes documented in cats: TOPICAL. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Esafoxolaner-Eprinomectin-Praziquantel in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: NexGard Combo
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| TOPICAL | Dose as printed in that source: 'For topical use in cats only.' 'the minimum dose of 0.055 mL/lb (0.12 mL/kg), which delivers a minimum dose of 0.65 mg/lb (1.44 mg/kg) esafoxolaner, 0.22 mg/lb (0.48 mg/kg) eprinomectin, and 4.53 mg/lb (9.98 mg/kg) praziquantel'; topical to the skin on the neck, once monthly; cats and kittens 8 weeks of age and older, weighing 1.8 lbs or greater | q30 days | Monthly, year-round | Fleas, ticks, heartworm, roundworms, hookworms, tapeworms | Strong | NEXGARD COMBO (esafoxolaner, eprinomectin and praziquantel) topical solution for cats — FDA Prescription Animal Drug Label, NADA 141-570, Boehringer Ingelheim Animal Health USA https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=48dd3eaa-18e3-430d-ad40-a964b591fb16 |
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Esafoxolaner (isoxazoline) for ectoparasites; eprinomectin (avermectin) for nematodes and heartworm; praziquantel for cestodes. Broadest spectrum feline parasite product.
Cats only. Monthly topical. First all-in-one product covering fleas, ticks, heartworm, roundworms, hookworms, and tapeworms in cats. Do not use in kittens <8 weeks.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Esafoxolaner-Eprinomectin-Praziquantel dose range in cats, with cited source references: TOPICAL Dose as printed in that source: 'For topical use in cats only.' 'the minimum dose of 0.055 mL/lb (0.12 mL/kg), which delivers a minimum dose of 0.65 mg/lb (1.44 mg/kg) esafoxolaner, 0.22 mg/lb (0.48 mg/kg) eprinomectin, and 4.53 mg/lb (9.98 mg/kg) praziquantel'; topical to the skin on the neck, once monthly; cats and kittens 8 weeks of age and older, weighing 1.8 lbs or greater q30 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Esafoxolaner-Eprinomectin-Praziquantel in cats: TOPICAL.
Cited course lengths for Esafoxolaner-Eprinomectin-Praziquantel in cats include: Monthly, year-round. Duration depends on the indication — match it to the specific dose rule in the table above.
Esafoxolaner-Eprinomectin-Praziquantel is indicated in cats for: Fleas, ticks, heartworm, roundworms, hookworms, tapeworms.
These are general warnings for Esafoxolaner-Eprinomectin-Praziquantel across species; consult the cat dosing table above for species-specific guidance. Cats only. Monthly topical. First all-in-one product covering fleas, ticks, heartworm, roundworms, hookworms, and tapeworms in cats. Do not use in kittens <8 weeks.
Why a species-specific page? Esafoxolaner-Eprinomectin-Praziquantel pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.