ExoticRx · exoticrx.com/drugs/ethosuximide
US brand names:Zarontin
Ethosuximide is dosed at 10–20 mg/kg PO q12h in cats, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Reduces low-threshold T-type calcium currents in thalamic neurons, suppressing the thalamocortical spike-wave discharge underlying absence seizures.
Specific for absence seizures only — not effective for generalized tonic-clonic seizures. GI upset common. Blood dyscrasias rare. Very limited veterinary use.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.